Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 14, Problem 10QP

a.

Summary Introduction

To determine: The combined frequency of two alleles used in DNA fingerprinting.

Introduction: The detection of variations in the minisatellites, or short tandem repeats used to identify individuals is called DNA fingerprinting. DNA was first used as forensic evidence in 1986.

b.

Summary Introduction

To determine: Whether the combined frequency of the alleles point to the suspect as a perpetrator

Introduction: DNA profiling has been used in criminal and civil investigations. The allele frequency with a number of STR probes is calculated, and the probability is matched with the suspect.

c.

Summary Introduction

To determine: The additional data that can be obtained from the DNA lab to find the perpetrator.

Introduction: The use of DNA profiling has brought about a major revolution in criminal and civil proceedings. The DNA is probed with four STR allele probes, and the frequency is calculated to determine or identify the perpetrator.

d.

Summary Introduction

To determine: Whether jurors in judicial system understand basic probability and whether DNA evidence can mislead jurors to make a false decision.

Introduction: DNA was first used as forensic evidence in 1986 since then DNA profiling has brought about a major revolution in criminal and civil proceedings. The analysis of DNA profiling includes the study of probability, statistics and population genetics.

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Police discovered the body of a woman who had been brutally assaulted. DNA from the crime scene was analysed and yielded the following SNP genotype: A1A2, G2G2, T1T2 for both the victim and a suspect. If the frequencies of A1, G1 and T1 alleles are 0.9, 0.99, 0.8 respectively, calculate the probability that another person in the group of suspects is responsible for the crime.
An important application of DNA fingerprinting is relationship testing. Persons who are related genetically have some bands or peaks in common. The number they share depends on the closeness of their genetic relationship. For example, an offspring is expected to receive half of his or her minisatellites from one parent and the rest from the other. The diagram shown here schematically illustrates traditional DNA fingerprints of an offspring, mother, and two potential fathers. In paternity testing, the offspring’s DNA fingerprint is first compared with that of the mother. The bands that the offspring have in common with the mother are depicted in purple. The bands that are not similar between the offspring and the mother must have been inherited from the father. These bands are depicted in red. Which male could be the father?
If only the first five loci listed in Table 1 of the assigned paper  (Forensics, DNA Fingerprinting, and CODIS) were analyzed, what would be the statistical probability of finding that particular genotype among people other than Suspect B? SHOW YOUR WORK!   Hint: Multiply together the frequencies of the individual STR genotypes to obtain the overall profile frequency.
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