Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 11, Problem 2TYU
The activation of receptor tyrosinc kinases is characterized by
(A) dimeiization and phosphorylation.
(B) dimerization and IP3 binding.
(C) a phosphorylation cascade.
(D) GTP liydrolysis.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Protein phosphorylation is commonly involved with all of thefollowing except(A) activation of receptor tyrosine kinases.(B) activation of protein kinase molecules.(C) activation of G protein-coupled receptors.(D) regulation of transcription by signaling molecules.
1) Amino acids that contain hydroxyl groups in their R-groups can be phosphorylated during cellular signaling.
(a) What amino acids can be phosphorylated? (use the one letter amino acid abbreviations)
(b) Does phosphorylation turn a signaling protein “on” or “off”?
(c) Whatis the most common source of a phosphate used to phosphorylate a protein
(d) What enzyme type (or category of enzymes)removes phosphates from proteins?
3) Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly.
The activated receptor stimulates a G protein, which opens a K+ channel in the
plasma membrane, as shown in Figure 1. Which of the following would enhance
this effect of the acetylcholine?
(a)
(b)
(c)
(d)
Figure 1
addition of a high concentration of a non-hydrolyzable analog of GTP
addition of a drug that prevents the a subunit from exchanging GDP for
GTP
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and acetylcholine
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and the G protein
Chapter 11 Solutions
Campbell Biology
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Prob. 1CCCh. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...
Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.4 - Prob. 4CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Prob. 7TYUCh. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
Additional Science Textbook Solutions
Find more solutions based on key concepts
2. A gene is a segment of DNA that has the information to produce a functional product. The functional product ...
Genetics: Analysis and Principles
Match the people in column A to their contribution toward the advancement of microbiology, in column B. Column ...
Microbiology: An Introduction (13th Edition)
1. The correct sequence of levels forming the structural hierarchy is
A. (a) organ, organ system, cellular, che...
Human Anatomy & Physiology (Marieb, Human Anatomy & Physiology) Standalone Book
Some people consider Pasteur or Koch to be the Father of Microbiology, rather than Leeuwenhoek. Why might they ...
Microbiology with Diseases by Body System (5th Edition)
The correct term for production of offspring. Introduction: Reproduction is an important life process for most ...
Biology Illinois Edition (Glencoe Science)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- (a) Predict the effect of a mutation that enhances the activity of the kinase associated with the PDH complex. (b) Predict the effect of a mutation that reduces the activity of the phosphatase associated with the PDH complex.arrow_forwardSignaling by tyrosine kinase receptors is generally associated with all of the following except: A) receptor dimerization B) growth factor responses C) heterotrimeric G proteins D) cross phosphorylation E) generating protein binding sites due to phosphorylationarrow_forwardSignaling molecules interact with cells through specific macromolecular receptors. For each of the four receptors identified below, list all characteris- tics, by number, which accurately describe that receptor. (a) An adrenergic receptor (b) A steroid receptor (c) The LDL receptor. (d) The insulin receptor, (1) Located at the cell surface (2) Associated with the protein clathrin (3) Ligand binding stimulates the activity of phospholipase C (4) A transmembrane protein (5) A DNA-binding protein (6) Located in the cell interior (7) Receptor-ligand complex moves to the lysosome (8) Receptor-ligand complex becomes concentrated in the nucleus (9) Receptor activation can inhibit the synthesis of glycogen (10) The hormone-receptor complex activates specific gene transcription (11) Internalization decreases the synthesis of cholesterol estersarrow_forward
- Receptor tyrosine kinases such as the epidermal growth factor (EGF) receptor can basically be broken down into three domains: (1) An extracellular, ligand binding domain, (2) A transmembrane domain that must cross through the cell membrane, and (3) an intracellular domain. Match the amino acid with the domain that it would MOST LIKELY be associated with. Lysine (choose (1), (2), or (3) from above) A tyrosine residue capable of being phosphorylated on its hydroxyl group (choose (1), (2), or (3) from above) Isoleucine (choose (1), (2), or (3) from above)arrow_forwardEndothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium. They have an important role in vascular homeostasis. Endothelin activates G protein-coupled receptors (GPCRs) ETA or ETB on a target cell. Which subunit of heterotrimeric G protein is released when the receptor is activated? a.) gamme b.) beta c.) alphaarrow_forwardBinding of a signaling molecule to which typeof receptor leads directly to a change in thedistribution of substances on opposite sides of themembrane?(A) intracellular receptor(B) G protein-coupled receptor(C) phosphorylated receptor tyrosine kinase dimer(D) ligand-gated ion channelarrow_forward
- Signaling by tyrosine kinase receptors is generally associated with all of the following except: OA) receptor dimerization B) growth factor responses C) heterotrimeric G proteins OD) cross phosphorylation E) generating protein binding sites due to phosphorylationarrow_forwardSignaling molecules interact with cells through specific macromolecular receptors. For each of the four receptors identified below, list all characteristics, by number, which accurately describe that receptor. (a) An adrenergic receptor (b) A steroid receptor (c) The LDL receptor (d) The insulin receptor (1) Located at the cell surface (2) Associated with the protein clathrin (3) Ligand binding stimulates the activity of phospholipase C (4) A transmembrane protein (5) A DNA-binding protein (6) Located in the cell interior (7) Receptor–ligand complex moves to the lysosome (8) Receptor–ligand complex becomes concentrated in the nucleus (9) Receptor activation can inhibit the synthesis of glycogen (10) The hormone–receptor complex activates specific gene transcription (11) Internalization decreases the synthesis of cholesterol esters (12) Action of this receptor diminishes the synthesis and activity of bhydroxy-b-methylglutaryl-CoA reductase (HMG-CoA reductase) (13) This receptor…arrow_forwardWith protein kinase-mediated molecular switches, downstream target molecules are typically activated by ... a) being phosphorylated b) binding to ATP c) the action of a phosphataase d) hydrolysis of GTP e) binding to GTParrow_forward
- Compare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.arrow_forwardActivation of certain GPCRs triggers an intracellular signaling mechanism that involves activation of adenlyl cyclase and an increase of cAMP. Which of the following statements best describes the the events that follow such a cAMP increase? a.) The cAMP increase leads to activation of protein kinase C. b.) The cAMP increase leads to activation of the release of the gamma subunit from the GPCR. c.) The cAMP increase leads to activation of protein kinase A.arrow_forwardAMPK and mTOR can both be considered intracellular signal integrators. Explain this definition.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License