Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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describe how the cellular response to EGF results in tissue repair (epidermal growth factor)
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- Hormone H regulates these effects via its receptors which are found at both the cell surface (csRH) and within the cell (içRH). The signalling pathways that become activated in the presence of hormone H are depicted and described below. hormone H. H H extracellular fluid inactive GTP inactive RAS Lyn cell-surface receptor for H (csR») icR GDP RAS-GTP hexose metabolism cell survival H icR G, phase (resting) Raf HK GSK-3P MEK M G2 icR - hexose kinase ERK promoter HRE CDK1 Cyclin A nucleus cyclin A Fos A promoter Created in BioRender.com bio Signalling via the cell surface receptor Hormone H mediates its cell cycle stimulatory and pro-survival effects by binding to and activating the cell surface hormone H receptor (csRH). The activated CSRH activates Lyn, which activates RAS and ultimately the Raf/MEK/ERK kinase cascade. Active ERK: o phosphorylates and inactivates GSK-3B. Inhibition of GSK-3ß promotes cell survival. inhibits p27, preventing it from inhibiting cell cycle progression.…arrow_forwardBriefly describe how inflammation can contribute to carcinogenesis and disease progression through heterotypic signaling.arrow_forwardCan you please describe the role of G proteins in ligand-activated cellular signal transduction.arrow_forward
- When comparing two or more ligands, a larger numerical value for KD corresponds to a higher binding affinity. True False In radioligand binding assays, a large excess of a noncompetitive antagonist is used to determine the specific binding of the radiolabeled ligand. True False Exocrine glands have ducts that provide a passageway for secretions to move to the surface of the epithelium. True False An inverse agonist binds to a receptor with an affinity that is inversely proportional to its potency. True False Can I get the answer? I don't need explanationarrow_forwardWhen taken in appropriate amounts, vitamin E protectsthe body from ROS. However, when it is taken in excessiveamounts vitamin E can potentially make the body moresusceptible to ROS. Explain.arrow_forwardYou are seeking a new anti-inflammatory drug to inhibit local responses to stress and injury. Which of the following activities would you look for in a potential anti-inflammatory agent? A It should function as a dominant-negative receptor for pro-inflammatory cytokines. It should be an agonist of a pro-inflammatory cytokine. C It should compete with the pro-inflammatory cytokine for the binding to its receptor. D It should function as a constitutively active receptor for pro-inflammatory cytokines. E It should facilitate the production of second messengers in response to a pro-inflammatory cytokine.arrow_forward
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