You are studying growth factor GFA, which you know stimulates the proliferation of goblet cells in the intestine. Goblet cells are responsible for producing and secreting mucin, a mixture of glycosaminoglycans that protects the intestinal wall. Some patients suffering from inflammatory bowel disease (IBD) appear to have fewer goblet cells, therefore less mucin and less protection from toxins and various other pro-inflammatory factors. These patients also have mutations in the gene encoding the GFA receptor (GFAR) in goblet cells, GFAR is a receptor tyrosine kinase (RTK) that autophosphorylates in response to GFA binding, thus becoming active. QUESTION: explain what changes in GFAR could be caused by these IBD-associated mutations and why.

You are studying growth factor GFA, which you know stimulates the proliferation of goblet cells in the intestine. Goblet cells are responsible for producing and secreting mucin, a mixture of glycosaminoglycans that protects the intestinal wall. Some patients suffering from inflammatory bowel disease (IBD) appear to have fewer goblet cells, therefore less mucin and less protection from toxins and various other pro-inflammatory factors. These patients also have mutations in the gene encoding the GFA receptor (GFAR) in goblet cells, GFAR is a receptor tyrosine kinase (RTK) that autophosphorylates in response to GFA binding, thus becoming active. QUESTION: explain what changes in GFAR could be caused by these IBD-associated mutations and why.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter3: The Plasma Membrane And Membrane Potential

Section: Chapter Questions

Problem 1ACR: When William H. was helping victims after a devastating earthquake in a region not prepared to...

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