Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Consider the mTOR pathway described below. Which of the following would be an example of negative feedback?
- Dephosphorylated PRAS40 activates PTEN lipid phosphatase activity.
- Active AKT leads to decreased expression of growth factor receptors.
- Active PKCα prevents PRAS40 from binding to mTOR.
- Active mTOR phosphorylates and activates AKT.
Transcribed Image Text:11T1
Growth factor
Growth factor receptor
РІЗК
PIP2
PIP..
PTEN
Enzymatic conversion
Activation
Inactivtion
►Leads to activation
AKT
PRAS40
mTOR
Other targets
PKCα
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