Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 3, Problem 64TQ
Summary Introduction
To review:
The
Introduction:
In biochemistry, acid dissociation constant or Ka is defined as a type of equilibrium constant that measures the tendency of a larger molecule to dissociate reversibly into smaller molecules. Carboxylic acid groupsionize to a lesser extent in water to form moderately acidic solutions. Carboxylic acids have -COOH as the
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Question 11. // Hint: Isoelectric focusing separates proteins based on their pI values, and can separate proteins that only differ by a net charge of ±1.±1. Recall that an amino acid residue with a negatively charged R group has a relatively low isoelectric point (pI) where it has zero net charge. Likewise, an amino acid residue with a positively charged R group has a relatively high isoelectric point (pI) where it has zero net charge. Order from Low pH to High pH
Question 4. Imagine the main chain of a protein bends
back on itself so that two amino acid residues R1 and R2
come close to each other.
In the table below are four possibilities for what R1 and
R2 might be. In each case, decide whether a specific
interaction could form between the residues. If a specific
interaction could form, give the name of the interaction.
R₁
cysteine
tyrosine
threonine
arginine
R₂
cysteine
phenylalanine
glutamine
aspartate
specific
interaction?
OO
yes
O yes
O no
no
OO
O yes
no
yes
no
name of specific
interaction
0
П
0
0
Can you please describe the specific components that each of these structures are comprised of ( alpha helices and beta sheets) in more detail? Also, what do the different colors represent?
Your reply will be greatly appreciated.
The ligand that was assigned to me is tadalafil.
Chapter 3 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 3 - Prob. 1QCh. 3 - Prob. 2QCh. 3 - Prob. 3QCh. 3 - Prob. 4QCh. 3 - Prob. 1RQCh. 3 - Prob. 2RQCh. 3 - Prob. 3RQCh. 3 - Prob. 4RQCh. 3 - Prob. 5RQCh. 3 - Prob. 6RQ
Ch. 3 - Prob. 7RQCh. 3 - Prob. 8RQCh. 3 - Prob. 9RQCh. 3 - Prob. 10RQCh. 3 - Prob. 11RQCh. 3 - Prob. 12RQCh. 3 - Prob. 13RQCh. 3 - Prob. 14RQCh. 3 - Prob. 15RQCh. 3 - Prob. 16RQCh. 3 - Prob. 17RQCh. 3 - Prob. 18RQCh. 3 - Prob. 19RQCh. 3 - Prob. 20RQCh. 3 - Prob. 21RQCh. 3 - Prob. 22RQCh. 3 - Prob. 23RQCh. 3 - Prob. 24RQCh. 3 - Prob. 25RQCh. 3 - Prob. 26RQCh. 3 - Prob. 27RQCh. 3 - Prob. 28RQCh. 3 - Prob. 29RQCh. 3 - Prob. 30RQCh. 3 - Prob. 31RQCh. 3 - Prob. 32RQCh. 3 - Prob. 33RQCh. 3 - Prob. 34RQCh. 3 - Prob. 35RQCh. 3 - Prob. 36FBCh. 3 - Prob. 37FBCh. 3 - Prob. 38FBCh. 3 - Prob. 39FBCh. 3 - Prob. 40FBCh. 3 - Prob. 41FBCh. 3 - Prob. 42FBCh. 3 - Prob. 43FBCh. 3 - Prob. 44FBCh. 3 - Prob. 45FBCh. 3 - Prob. 46SACh. 3 - Prob. 47SACh. 3 - Prob. 48SACh. 3 - Prob. 49SACh. 3 - Prob. 50SACh. 3 - Prob. 51TQCh. 3 - Prob. 52TQCh. 3 - Prob. 53TQCh. 3 - Prob. 54TQCh. 3 - Prob. 55TQCh. 3 - Prob. 56TQCh. 3 - Prob. 57TQCh. 3 - Prob. 58TQCh. 3 - Prob. 59TQCh. 3 - Prob. 60TQCh. 3 - Prob. 61TQCh. 3 - Prob. 62TQCh. 3 - Prob. 63TQCh. 3 - Prob. 64TQCh. 3 - Prob. 65TQCh. 3 - Prob. 66TQCh. 3 - Prob. 67TQCh. 3 - Prob. 68TQCh. 3 - Prob. 69TQCh. 3 - Prob. 70TQCh. 3 - Prob. 71TQCh. 3 - Prob. 72TQCh. 3 - Prob. 73TQCh. 3 - Prob. 74TQCh. 3 - Prob. 75TQCh. 3 - Prob. 76TQ
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Similar questions
- Multisubunit proteins in which some or all of the subunitsare identical are referred to as _______________________.arrow_forwardWhen a purine or a pyrimidine is linked through a β-N-glycosidic link to C-1 of a pentose, the molecule is called a _____________ .arrow_forwardA posttranslational modification that directs a polypeptide toa specific site is called a _____________________modification.arrow_forward
- When the “head and tail” structural model is applied to a glycerophospholipid, the two tails arearrow_forwardThe figure below shows the titration curve for the amino acid aspartic acid. There are five key points in the titration designated with roman numerals. For each of the statements following the figure, identify the appropriate key point of the titrationarrow_forwardA posttranslational modification that directs a polypeptide to a specific location is called a _____________ modification.arrow_forward
- The _____________ is an explanation for why there are fewer tRNAs than expected in living cells.arrow_forwardProteins are composed of both polar (hydrophilic) and nonpolar (hydrophobic) amino acids. Assume you are starting with fresh homogenized/pasteurized cow's milk. A major protein in the milk is a whey protein known as alpha-lactalbumin (in a tertiary structure). If this protein is denatured (for example by the introduction of heat, acid, or other means), discuss how and why scientifically it could end up becoming an effective emulsifier in a product containing olive oil and red wine vinegar.arrow_forwardSphingolipid storage diseases (sphingolipidoses) are inherited diseases caused by abnormal accumulation of membrane lipids. Elaborate on the molecular basis behind Tay-Sachs disease. Note: I expect a genuine explanation toward this question!arrow_forward
- Suggest a reason (or reasons) why amino acids polymerize to form proteins that have comparatively few covalent crosslinks in the polypeptide chain.arrow_forwardHeparin, a highly negatively charged glycosaminoglycan, is used clinically as an anticoagulant. It acts by binding several plasma proteins, including antithrombin III, an inhibitor of blood clotting. The 1:1 binding of heparin to antithrombin III seems to cause a conformational change in the protein thatgreatly increases its ability to inhibit clotting. What amino acid residues of antithrombin III are likely to interact with heparin?arrow_forwardGlycine is a highly conserved amino acidresidue in proteins (i.e., it is found in the same position in theprimary structure of related proteins). Suggest a reason why thismight occur.arrow_forward
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