Biology 2e
Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 9, Problem 15RQ

How does NF-kB induce gene expression?

  1. A small, hydrophobic ligand binds to NF-kB, activating it.
  2. Phosphorylation of the inhibitor Ik-B dissociates the complex between it and NF- kB, and allows NF-kB to enter the nucleus and stimulate transcription.
  3. NF-kB is phosphorylated and is then free to enter the nucleus and bind DNA.
  4. NF-kB is a kinase that phosphorylates a transcription factor that binds DNA and promotes protein production.

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