Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 9, Problem 30CTQ
If a cell developed a mutation in its MAP2K1 gene (encodes the MEK protein) that prevented MIEK from being recognized by phosphatases, how would the EGFR signaling cascade and the cell’s behavior change?
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Put the following steps for the outline of the growth factor signaling pathway in order:
Map Kinase Kinase is Phosphorylated
Proteins involved in gene transcription are activated
Growth factor binds to its receptor in the cytoplasmic membrane
Receptor recruits adaptor protein and GEF
Autophosphorylation of tyrosine residues on the receptor
Structural change of the receptor activates Tyrosine Kinase
Map Kinase Kinase Kinase is phosphorylated
Ras, a small GTPase, is activated by the exchange of GTP for GDP
Map Kinase is Phosphorylated
Map Kinase enters the nucleus
Which components of the phosphoinositide signaling system are soluble and which are associated with the membrane?
What is the function of Ras during tyrosine kinase cell signaling?
a. It activates the opening of channel-linked receptors.
b. It is an enzyme that synthesizes second messengers.
c. It links the receptor protein to the MAP kinase pathway.
d. It phosphorylates other enzymes as part of a pathway.
Chapter 9 Solutions
Biology 2e
Ch. 9 - Figure 9.8 HER2 is a receptor tyrosine kinase. In...Ch. 9 - Figure 9.10 In certain cancers, the GTPase...Ch. 9 - Figure 9.17 Which of the following statements...Ch. 9 - Figure 9.18 What advantage might biofilm...Ch. 9 - What property prevents the ligands of cell-surface...Ch. 9 - The secretion of hormones by the pituitary gland...Ch. 9 - Why are ion channels necessary to transport ions...Ch. 9 - Endocrine signals are transmitted more slowly than...Ch. 9 - A scientist notices that when she adds a small,...Ch. 9 - Where do DAG and IP3 originate? They are formed by...
Ch. 9 - What property enables the residues of the amino...Ch. 9 - Histamine binds to the H1 G-protein-linked...Ch. 9 - A scientist observes a mutation in the...Ch. 9 - What is the function of a phosphatase? A...Ch. 9 - How does NF-kB induce gene expression? A small,...Ch. 9 - Apoptosis can occur in a cell when the cell is...Ch. 9 - What is the effect of an inhibitor binding an...Ch. 9 - How does PKC’s signaling role change in response...Ch. 9 - A scientist notices that a cancer cell line fails...Ch. 9 - Which type of molecule acts as a signaling...Ch. 9 - Quorum sensing is triggered to begin when...Ch. 9 - A doctor is researching new ways to treat biofilms...Ch. 9 - What is the difference between intracellular...Ch. 9 - How are the effects of paracrine signaling limited...Ch. 9 - What are the differences between internal...Ch. 9 - Cells grown in the laboratory are mixed with a dye...Ch. 9 - Insulin is a hormone that regulates blood sugar by...Ch. 9 - The same second messengers are used in many...Ch. 9 - What would happen if the intracellular domain of a...Ch. 9 - If a cell developed a mutation in its MAP2K1 gene...Ch. 9 - What is a possible result of a mutation in a...Ch. 9 - How does the extracellular matrix control the...Ch. 9 - A scientist notices that a cancer cell line shows...Ch. 9 - What characteristics make yeasts a good model for...Ch. 9 - Why is signaling in multicellular organisms more...Ch. 9 - Pseudomonas infections are very common in hospital...
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