Concept explainers
QUANTITATIVE Gorter and Grendel Revisited. Gorter and Grendel’s classic conclusion that the plasma membrane of the human erythrocyte consists of a lipid bilayer was based on the following observations: (i) the lipids that they extracted with acetone from 4.74 × 109 erythrocytes formed a monolayer 0.89 m2 in area when spread out on a water surface, and (ii) the surface area of one erythrocyte was about 100 µm2, according to their measurements.
(a) Show from these data how they came to the conclusion that the erythrocyte membrane is a bilayer.
(b) We now know that the surface area of a human erythrocyte is about 145 µm2. Explain how Gorter and Grendel could have come to the right conclusion when one of their measurements was only about two-thirds of the correct value.
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Becker's World of the Cell (9th Edition)
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