Analyze the effect on DNA replication if mutation of DNA pol III loses each of the following activities, 5 ' → 3 ' polymerase activity. 3 ' → 5 ' exonuclease activity. Introduction: DNA replication is one of the basic and important processes that occurs within the cell in which a double stranded DNA molecule is copied to produce two identical DNA molecules. In prokaryotes, the replication of DNA is bidirectional, which is, processing from a single point of origin of replication to both directions, and the series of proteins and enzymes are involved in the replication mechanism. One of the important enzymes in the DNA replication mechanism is DNA polymerase III. The main replicative enzyme is DNA polymerase III. It synthesizes a new DNA strand in 5 ' − 3 ' direction.

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Answer 1

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Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 7, Problem 33P

Summary Introduction

To analyze:

Analyze the effect on DNA replication if mutation of DNA pol III loses each of the following activities,

5'→3' polymerase activity.

3'→5' exonuclease activity.

Introduction:

DNA replication is one of the basic and important processes that occurs within the cell in which a double stranded DNA molecule is copied to produce two identical DNA molecules. In prokaryotes, the replication of DNA is bidirectional, which is, processing from a single point of origin of replication to both directions, and the series of proteins and enzymes are involved in the replication mechanism.

One of the important enzymes in the DNA replication mechanism is DNA polymerase III. The main replicative enzyme is DNA polymerase III. It synthesizes a new DNA strand in 5'−3' direction.

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what if a mutation resulted in the enzyme DNA polymerase III being non-functional? How would that affect DNA replication

Describe three (3) effects on DNA replication if DNA polymerase could build DNA in both directions – in both the 5’ to 3’ direction and the 3’ to 5’ direction.

Match the enzymes provided from (1-4) in the list of choices with their matching function (A-D) during DNA replication. A. Disrupts hydrogen bonds between DNA bases B. Can only add nucleotides to an existing 3 OH end C. Can't add nucleotides to a chain, but can make covalent bonds D. Actually a specialized form of RNA polymerase select 1. DNA polymerase select 2. Primase select 3. Ligase select v 4. Helicase

Answer 2

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 7, Problem 33P

Summary Introduction

To analyze:

Analyze the effect on DNA replication if mutation of DNA pol III loses each of the following activities,

5'→3' polymerase activity.

3'→5' exonuclease activity.

Introduction:

DNA replication is one of the basic and important processes that occurs within the cell in which a double stranded DNA molecule is copied to produce two identical DNA molecules. In prokaryotes, the replication of DNA is bidirectional, which is, processing from a single point of origin of replication to both directions, and the series of proteins and enzymes are involved in the replication mechanism.

One of the important enzymes in the DNA replication mechanism is DNA polymerase III. The main replicative enzyme is DNA polymerase III. It synthesizes a new DNA strand in 5'−3' direction.

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Answer 3

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 7, Problem 33P

Summary Introduction

To analyze:

Analyze the effect on DNA replication if mutation of DNA pol III loses each of the following activities,

5'→3' polymerase activity.

3'→5' exonuclease activity.

Introduction:

DNA replication is one of the basic and important processes that occurs within the cell in which a double stranded DNA molecule is copied to produce two identical DNA molecules. In prokaryotes, the replication of DNA is bidirectional, which is, processing from a single point of origin of replication to both directions, and the series of proteins and enzymes are involved in the replication mechanism.

One of the important enzymes in the DNA replication mechanism is DNA polymerase III. The main replicative enzyme is DNA polymerase III. It synthesizes a new DNA strand in 5'−3' direction.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 7, Problem 33P

Summary Introduction