Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 7, Problem 26P
Telomeres are found at the ends of eukaryotic chromosomes.
a. What is the sequence composition of telomeres?
b. How does telomerase assemble telomeres?
c. What is the functional role of telomeres?
d. Why is telomerase usually active in germ-line cells but not in somatic cells?
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Chapter 7 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 7 - What results from the experiments of Frederick...Ch. 7 - 7.2 Explain why Avery, MacLeod, and McCarty’s in...Ch. 7 - 7.3 Hershey and Chase selected the bacteriophage...Ch. 7 - 7.4 Explain how the Hershey and Chase experiment...Ch. 7 - 7.5 One strand of a fragment of duplex DNA has the...Ch. 7 - 7.6 The principles of complementary base pairing...Ch. 7 - For the following fragment of DNA, determine the...Ch. 7 - 7.8 Figures present simplified depictions of...Ch. 7 - 7.9 Consider the sequence -ACGCTACGTC-.
What is...Ch. 7 - DNA polymerase III is the main DNA-synthesizing...
Ch. 7 - There is a problem completing the replication of...Ch. 7 - Explain how RNA participates in DNA replication.Ch. 7 - A sample of double-stranded DNA is found to...Ch. 7 - Bacterial DNA polymerase I and DNA polymerase III...Ch. 7 - Diagram a replication fork in bacterial DNA and...Ch. 7 - Prob. 16PCh. 7 - Which of the following equalities is not true for...Ch. 7 - List the order in which the following proteins and...Ch. 7 - Two viral genomes are sequenced, and the following...Ch. 7 - Matthew Meselson and Franklin Stahl demonstrated...Ch. 7 - Raymond Rodriguez and colleagues demonstrated...Ch. 7 - 7.22 Joel Huberman and Arthur Riggs used pulse...Ch. 7 - 7.23 Why do the genomes of eukaryotes, such as...Ch. 7 - Bloom syndrome (OMIM 210900) is an autosomal...Ch. 7 - 7.25 How does rolling circle replication (see...Ch. 7 - Telomeres are found at the ends of eukaryotic...Ch. 7 - A family consisting of a mother (I-1), a father...Ch. 7 - In a dideoxy DNA sequencing experiment, four...Ch. 7 - Prob. 29PCh. 7 - Using an illustration style and labeling similar...Ch. 7 - A PCR reaction begins with one double-stranded...Ch. 7 - Prob. 32PCh. 7 - Prob. 33PCh. 7 - 7.34 A sufficient amount of a small DNA fragment...Ch. 7 - You are participating in a study group preparing...Ch. 7 - Prob. 36PCh. 7 - The following diagram shows the parental strands...Ch. 7 - Go to the OMIM website...
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- Cells lacking telomerase can grow for several cell divisions without obvious defects. However, after more cell divisions, such cells tend to show chromosomes that have fused together. Propose an explanation for the formation of the chromosomes.arrow_forwardConsider how histone proteins bind to DNA and then explain whya high salt concentration can remove histones from DNA (asshown in 10.18b).arrow_forward4. Which statement about telomeres is incorrect? A) Telomeres are repetitive nucleotide sequences at- the end of a chromatid B) Telomeres serve as protective caps that prevent chromosome from deterioration during cell division C) Telomeres are gradually consumed during repeated the cell divisions D) In cancer cells, telomerase activity is usually re- duced compared with normal cellsarrow_forward
- Certain organisms contain cells that possess polytene chromosomes. What are polytene chromosomes, where are they found, and what function do they serve?arrow_forwardA. In NOT more than 200 words, explain how the double-helical structure of DNA suggests a mechanism for DNA replication? B. In NOT more than 200 words, explain the special mechanism used to replicate chromosome ends?arrow_forwardBob's telomerase works extremely well (10x better than the average humans). Explain the function of telomerase in normal people. Describe one advantage to Bob that you would predict. Describe one disadvantage for Bob you might predict. (3 sentences)arrow_forward
- (a)Discuss or explain the consequences for a cell if the chromatin could not be remodeled. (b) Does the action of the telemorase enzyme contradict the central dogma of molecular biology? why or why not?arrow_forwardDefine telomere and describe the possible connections between telomerase and cell aging and between telomerase and cancer.arrow_forwardScientists identify a tumor cell in rats that divides more rapidly in the presence of galactose. When they sequence the DNA of the tumor cells, they identify retroviral DNA. Explain what circumstances might have occurred that produced this phenotype.arrow_forward
- The telomeres of a linear chromosome are made of identical directly repeated DNA sequences. How does the enzyme telomerase generate these DNA repeats?arrow_forwardExplain why cheek cells are diploid, and how does this affect the DNA?arrow_forwardMany chromosomes have structures called telomeres at each end. Mark all the TRUE statements about telomeres below. Mark all that apply. Select one or more: a. Telomeres protect the ends of the chromosomes b. Telomeres hold sister chromatids together after replication c. Human telomeres consist of a specific base sequence (TTAGGG) repeated about 2500 times d. Telomeres are present in all prokaryotes and eukaryotesarrow_forward
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