To determine: The events that take place during the process of amplification.
Introduction: The communication between the cells is essential to transport information to the cells. Cell-to-cell communication is done with the help of signal transduction pathways. Signal transduction pathway initiates a series of events, which generates the extracellular response.
To determine: The number of signaling molecules that are amplified in the figure is given in the book.
Introduction: Signal transduction pathway is a series of events that transfer the particular information to the cells. This pathway begins when a ligand attaches with a receptor present on the cells. The signals carried by a ligand are not sufficient to generate the response. Hence, these signals are amplified to produce a response.
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Human Physiology: An Integrated Approach (8th Edition)
- Describe how a very small quantity of receptor ligand is capable of eliciting a strong response in a target cell through amplification.arrow_forwardPathways involving G proteins provide an opportunityfor an increase in signal strength in the course of signaltransduction, a change referred to as amplification.How might this be beneficial in olfaction?arrow_forwardWhich receptor undergoes clustering and autophosphorylation in response to activation by a signal? Group of answer choices: a)Ligand-gated ion channels b)Receptor Tyrosine Kinases (RTKs) c)G-Protein Coupled Receptors (GPCRs) d)Nuclear Receptorsarrow_forward
- Select only one of these types of GPCR and describe the signal transduction that is involved in that receptor.arrow_forwardBriefly discuss the mechanism in receptor signal transductionarrow_forwardWhat is the mechanism by which voltage-gated channels open in response to voltage changes? Choose the best answer: (a) Voltage changes cause release of ligand (b) Voltage changes shift the receptor from the inactivated to active state (c) Charged residues in the channel lead to a conformation change (d) Voltage changes lead to increased force from ions attempting to pass through (e) Voltage changes increase ion channel expression I wish to select answer (c), but I am not sure it is the best answer compared with (b) and (d). Thus I wish to seek your expertise advice.arrow_forward
- How is an extracellular signal converted to an intracellular signal in signal transduction? Give a specific example.arrow_forwardA common membrane-bound intermediary between the receptor and the effector protein within the plasma membrane is the __________________.arrow_forwardParkinson's Disease Parkinson's disease is neurodegenerative disorder that affects movement. Most people affected with Parkinson's disease demonstrate rigidity, slow movement, and shaking. The symptoms of Parkinson's disease occur when the cells that produce dopamine neurotransmitters die in the brain. Explain how the signal transmission at a synapse in an individual with Parkinson's disease is different than an unaffected individual. Describe the normal process of signal transmission at a synapse. Start with the arrival of an action potential at the axon terminal and include the name of the neurotransmitter that is affected by Parkinson's disease. Explain how the process is different in individuals affected with Parkinson's disease.arrow_forward
- You recently read about Justin Bieber's unfortunate run-ins with glass doors and walls. Since then, you learned about how neurons are the unique cell of the nervous system and that signals are sent via action potential along those cells. You have further learned about how signals "jump" from one neuron to the next, allowing for your nervous system to function every single day. Explain, using language from your learning of signal transduction and the nervous system, just what Justin Bieber's neurons should have been doing to prevent his unfortunate accidents. In other words, describe how are signals received, sent, and passed along in the nervous system (a system primarily responsible for preventing people from walking into doors and walls). You may enhance your answer by comparing the effects of drug use with the inability to avoid these accidents. *Hint: half of your response should be about neuron anatomy and action potential and the other half should be about signaling across…arrow_forwardExplain whether the specificity of interaction will be high or low for each given situation. a. The value of KD of the ligand's interaction to the target receptor is very much lower than the value of KD of the ligand's interaction to off-targets. b. The ligand concentration [L] is higher than the KD value of its interaction with the target and the KD value of its interaction to off-targets.arrow_forwarddescribe how signal amplification is accomplished in target cellarrow_forward
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