Concept explainers
(a)
To determine: Whether a cell depolarize or hyperpolarize when Cl- channel opens.
Introduction: Polarization is the electric difference across the cell membrane. It is the process of producing positive and negative electric charges inside the cell with respect to the surroundings.
(b)
To determine: Whether a cell depolarize or hyperpolarize when K+ channel opens.
Introduction: Resting potential of a cell is -70 mV. When resting potential alters, the cell either becomes hyperpolarize or depolarize. It becomes more negative or more positive.
(c)
To determine: Whether a cell depolarize or hyperpolarize when Na+ channel opens.
Introduction: At rest, a neuron has a resting potential of -70 mV. This states that inside of the cell is more negatively charged than the surrounding. When resting potential increases or decreases, a neuron transmits the message.
Want to see the full answer?
Check out a sample textbook solutionChapter 6 Solutions
Human Physiology: An Integrated Approach (8th Edition)
- The resting membrane potential is established by? The Na+/K+-ATPase pumping Na+ into the cell and K+ out of the cell The Na+/K+-ATPase pumping K+ into the cell and Na+ out of the cell A larger diffusion of K+ out of the cell compared to diffusion of Na+ into the cell A larger diffusion of K+ into the cell compared to diffusion of Na+ out of the cell a) and d) b) and c)arrow_forwardWhich of the following statements about the sodium-potassium pump is correct? A) Both sodium and potassium move down their concentration gradient across the membrane B) 2 sodium ions are pumped out of the cell against their concentration gradient C) The sodium-potassium pump is a type of cotransport. D) ATP is used as an energy sourcearrow_forwardInterpret the effect of hyperkalemia with reference to Goldman’s equation. a) What happens to rate of K+ diffusion at the MRP equilibrium with elevated extracellular [K+] (and unchanged intracellular [K+])?b) Since this diffusion rate determines the “permeability” of the cell to that K+ ion, what happens to PK+ as a result of this elevated extracellular K+? (Hint- it HAS changed.)c) Since PK+ has changed, and PNa+ is unchanged, what happens to the MRP as a result of this change in PK+? Explain with specific reference to Goldman’s equation but there is no need to cite or calculate any specific numbers, just generalize the result.arrow_forward
- Cells normally exist in a steady state where the intracellular ions remain constant. How is this steady state achieved by limiting the effect of extracellular ions on ions in the cells?arrow_forwardPlease answer both questions: 1) The sodium-potassium pump: a) equalizes the charge distribution across the cell membrane. b) transports K+ into the cell where it is in high concentration. c) requires very little energy expenditure on the part of nerve cells. d) establishes concentration gradients across the cell membrane. 2) Membrane potentials are always expressed comparing the inside of the cell relative to the outside of the cell. The resting membrane potential is -70 mV because the inside of the cell accumulates ions with negative charges. a) True b) Falsearrow_forwardBriefly describe, how P-type transporters helps in transporting ions? (Subject: Biomembrane)arrow_forward
- What is the application of electrical application in Cell Membrane potential gradient?arrow_forwardIn the experimental setup described in the attached figure (Figure 2.5 of the textbook), the middle panel shows two compartments with 10 mM KCI on the left (inside) and 1 mM KCL on the right (outside), separated by a membrane that is permeable to K+. What would initially happen if you replaced the KCI solutions with NaCl solutions (1 mM on the left or inside and 10 mM on the right or outside)? (A) Inside 1 mM KC Voltmeter Outside 1 mM KCI Permeable to K Nonet Bux of K (B) Initial conditions Initially Inside Outside 10 mM KC 1 mM KC Net flux of K from inside in outside → At equilibrium --58 mY Inside Outside 10 mM KCI 1 mM KC Flux of K from inside to outside balanced by opposing membrare potential Membrane potential (A) -116 [KL] 4 tended change O Na+ would move up its concentration gradient from the left (inside) to the right (outside) compartment. O Na+ would move down its concentration gradient from the right (outside) to the left (inside) compartment. O Na+ would not move because…arrow_forwardSimilarly, what will be the effect on membrane potential if Cl- ions move into a cell?arrow_forward
- Explain the mechanism of action of the Na+/K+ pump. If these pumps became non-functional due to a genetic mutation, what do you think would be the expected effect on the electrochemical membrane potential of the cell? Explain your reasoning.arrow_forwardhttps://www.youtube.com/watch?v=_bPFKDdWlCg&feature=youtu.be – Na/K pump Answer the following question: How does the movement of three positive Na ions out of the cell and two positive K ions into the cell make the inside of the cell negative?arrow_forwardThe inside negative membrane potential is a force that helps support... a.) the movement of (neutral) nonelectrolytes into the cell b.) the movement of cations into the cell c.) the movement of (neutral) nonelectrolytes out of the cell d.) the movement of anions into the cellarrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning