The most probable explanation for the observations that replacement of glycine (G) with alanine (A) or serine (S) does not change the shape of a protein, while replacement of G with valine (V) results in the change in the protein’s shape. Introduction: A change in the protein shape takes place with even a small change in its amino acid sequence. For example, the glycine resides at a particular location in a protein and makes certain interactions with other amino acids. Replacement of glycine with arginine (R) or glutamic acid (Q) results in a considerable change in the shape of protein near the amino acid change.

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Chapter 3.2, Problem 2R

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The most probable explanation for the observations that replacement of glycine (G) with alanine (A) or serine (S) does not change the shape of a protein, while replacement of G with valine (V) results in the change in the protein’s shape.

Introduction:

A change in the protein shape takes place with even a small change in its amino acid sequence. For example, the glycine resides at a particular location in a protein and makes certain interactions with other amino acids. Replacement of glycine with arginine (R) or glutamic acid (Q) results in a considerable change in the shape of protein near the amino acid change.

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