Human Anatomy & Physiology (2nd Edition)
2nd Edition
ISBN: 9780134553511
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 3, Problem 3AYKA
Summary Introduction
To review:
The impact of a hypothetical poison on mitosis, which prevents transcription factors from binding (or attaching) to the gene for tubulin proteins.
Introduction:
Mitosis represents the division of chromosomes (or genetic material) between two daughter cells. It needs a structure termed as mitotic spindle, which is made of microtubules arranged into spindle fibers by the centrosomes of a cell.
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A hypothetical poison prevents transcription factors from binding to the gene for tubulin proteins. What impact would this have on mitosis, and why?
The anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death?
List in each blank the description of events associated with each stage of mitosis in addition to the preparatory stage Interphase. Some events and structures occur only in plant cells and some in animal cells. Mark these events in the list with an asterisk.
Chapter 3 Solutions
Human Anatomy & Physiology (2nd Edition)
Ch. 3.1 - What general processes are carried out by cells?Ch. 3.1 - Prob. 2QCCh. 3.1 - Where are intracellular and extracellular fluids...Ch. 3.2 - 1. How do phospholipids arrange themselves in the...Ch. 3.2 - 2. How is the plasma membrane described according...Ch. 3.2 - 3. What are five functions of membrane proteins?
Ch. 3.2 - What roles do cholesterol, glycoproteins, and...Ch. 3.3 - Mark each of the following statements as true or...Ch. 3.3 - Mark each of the following statements as true or...Ch. 3.3 - Mark each of the following statements as true or...
Ch. 3.3 - Mark each of the following statements as true or...Ch. 3.3 - How does the process of primary active transport...Ch. 3.3 - What is the main primary active transport pump in...Ch. 3.3 - 7. How does the process of secondary active...Ch. 3.3 - Prob. 8QCCh. 3.3 - Explain the basic process of exocytosis.Ch. 3.4 - 1. Identify the properties listed in the next...Ch. 3.4 - Identify the following properties as belonging to...Ch. 3.4 - To what destinations can products from the Golgi...Ch. 3.5 - Prob. 1QCCh. 3.5 - Prob. 2QCCh. 3.5 - Prob. 3QCCh. 3.6 - 1. What are the main components of the nucleus?...Ch. 3.6 - What is chromatin? How are chromatin and...Ch. 3.6 - 3. What is a nucleolus, and what is its...Ch. 3.7 - How is a codon related to a triplet?Ch. 3.7 - 2. Describe the basic steps of transcription.
Ch. 3.7 - Explain how tRNA acts as the translator of the...Ch. 3.7 - Describe the basic steps of translation.Ch. 3.7 - 5. Why is posttranslational modification...Ch. 3.7 - 6. Why is it important to regulate gene...Ch. 3.8 - What happens during each stage of the cell cycle?Ch. 3.8 - What does semiconservative replication mean?Ch. 3.8 - Describe the changes in the cell that take place...Ch. 3.8 - What are four external factors that play a role in...Ch. 3 - Which of the following is not a basic function...Ch. 3 - Prob. 2CYRCh. 3 - What are the two fluid compartments in the body,...Ch. 3 - 4. Which of the following best describes the...Ch. 3 - Mark the following statements about the plasma...Ch. 3 - 6. What is the primary difference between active...Ch. 3 - 7. Match the term with its appropriate...Ch. 3 - 8. Fill in the blanks: A hypotonic solution will...Ch. 3 - 9. Match the following terms with the correct...Ch. 3 - Prob. 10CYRCh. 3 - Mark the following statements about the...Ch. 3 - 12. Our somatic cells’ DNA is distributed among...Ch. 3 - Explain how and why chromatin is condensed in the...Ch. 3 - Which of the following statements correctly...Ch. 3 - Each of the following statements about protein...Ch. 3 - Number the following steps of protein synthesis in...Ch. 3 - Which of the following is not a phase of mitosis?...Ch. 3 - 18. Why is regulation of the cell cycle...Ch. 3 - 19. Mark the following statements about the cell...Ch. 3 - 20. Match the following terms with the correct...Ch. 3 - 1. Write a single sentence, using no more than 25...Ch. 3 - 2. Certain diseases are transmitted via...Ch. 3 - 3. Explain how the form of each of the following...Ch. 3 - Certain types of cancerous lung tumors can secrete...Ch. 3 - Why do you think the rate of cell division is...Ch. 3 - 1. A patient is admitted to the hospital and...Ch. 3 - A popular science fiction program once had an...Ch. 3 - Prob. 3AYKACh. 3 - Prob. 4AYKACh. 3 - The drug methotrexate is used to treat several...
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- (b) What is the role of microtubules in mitosis? How does vincristine contribute to the cell cycle arrest of cancer cells? Explain. Microtubulesarrow_forwardWhat is the name of the structure that the microtubules bind to during mitosis?arrow_forwardThe drug chloral hydrate prevents elongation of microtubules by preventing the addition of new subunits to the growing end. During which stage of mitosis would chloral hydrate be most harmful?arrow_forward
- Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forwardWhat processes occur in the interphase cell before the onset of mitosis? Why is it incorrect to say that these cells are resting?arrow_forwardIn mitosis, why do the chromosomes need to condense in prophase and line up in metaphase? (To be clear, this is asking about the usefulness of these specific actions, not just that those things need to happen as part of the overall process.)arrow_forward
- In Xenopus, one of the substrates of mitotic CDKs is the phosphatase Cdc25. When phosphorylated by mitotic CDKs, Cdc25 is activated. What is the substrate of Cdc25? How does this information help to explain the rapid rise in mitotic CDK activity as cells enter mitosis?arrow_forwardWhat experimental evidence indicates that cyclin B is re-quired for a cell to enter mitosis? What evidence indicates that cyclin B must be destroyed for a cell to exit mitosis?arrow_forwardWhat effect does colchicine have on the percentage of cells in EACH of the stages of mitosis?arrow_forward
- In the following study, the investigators wanted to determine the role of cyclin B in controlling the cell cycle. Earlier researchers had found that extracts made from frog eggs (Xenopus) contained all the necessary proteins and machinery required for DNA replication. This included proteins that regulated the mitosis promoting factor (MPF). At the time of this study, cyclin B was show to affect MPF activity and the research group wanted to test using Xenopus egg extract in an assay. In Figure 1 (a) MPF activity was tested for its ability to phosphorylate Histone (H1) in sperm chromatin over a certain period of time. Additionally, the cyclin B concentration in the extract was measured. In figure 1b, the extract was tested after treatment with RNase which degraded only the mRNA and not RNA or FRNA in the extract. Knowing that cyclin B is a short-lived protein, why do you suppose the graph shows the results you see in figure 1b?arrow_forwardIn normally dividing cells, once chromosomes have been properly segregated via the steps of mitosis, the two resulting “daughter cells” separate. In animal cells (and other cell types without a cell wall) the contractile ring plays a crucial role in the process of cytokinesis. Exactly how the contractile ring is accurately positioned, so as to be located midway between the two poles (ends) of the dividing cell, is still not fully understood, although factors released from the mitotic spindle are thought to play a role.Regardless of the precise positioning mechanism, one key player in the assembly of the contractile ring is the GTP/GDP binding protein Rho. In its active form, Rho can stimulate the activity of the actin-binding protein formin and (via effects on the myosin regulatory light chain) that of myosin II. Given their respective roles, why might activation of formin and myosin II be beneficial as cells assemble a functional contractile ring structure?arrow_forwardWhich stage of mitosis is critical or important in both animal and plant cells? Why?arrow_forward
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