Organic Chemistry
5th Edition
ISBN: 9780078021558
Author: Janice Gorzynski Smith Dr.
Publisher: McGraw-Hill Education
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Question
Chapter 3, Problem 3.55P
Interpretation Introduction
(a)
Interpretation: The product of the reaction of acebutolol with HCl is to be drawn.
Concept introduction: The most basic
Interpretation Introduction
(b)
Interpretation: The solubility of acebutolol and its hydrochloride salt in water is to be discussed.
Concept introduction: The solubility of a compound depends on its interactions with the solvent molecule.
Interpretation Introduction
(c)
Interpretation: The reason as to why acebutolol is marketed as a hydrochloride salt rather than a neutral molecule is to be stated.
Concept introduction: The drug having more solubility is marketed for its maximum utilization.
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Many drugs are sold as their hydrochloride salts (R,NH2* CI), formed by reaction of an amine (R,NH) with HCI.
он
acebutolol
a. Draw the product (a hydrochloride salt) formed by reaction of acebutolol with HCI. Acebutolol is a ß blocker used to treat
high blood pressure.
b. Discuss the solubility of acebutolol and its hydrochloride salt in water.
c. Offer a reason as to why the drug is marketed as a hydrochloride salt rather than a neutral amine.
Many drugs are sold as their hydrochloride salts (R2NH2+ Cl−), formed by reaction of an amine (R2NH) with HCl.
a.Draw the product (a hydrochloride salt) formed by reaction of acebutolol with HCl. Acebutolol is a β blocker used to treat high blood pressure.
b. Discuss the solubility of acebutolol and its hydrochloride salt in water. c.Offer a reason as to why the drug is marketed as a hydrochloride salt rather than a neutral amine.
Many drugs are sold as their hydrochloride salts (R2NH2+ Cl−), formed by reaction of an amine (R2NH) with HCl.
a. Draw the product (a hydrochloride salt) formed by reaction of acebutolol with HCl. Acebutolol is a β blocker used to treat high blood pressure.
b. Discuss the solubility of acebutolol and its hydrochloride salt in water.
c. Offer a reason as to why the drug is marketed as a hydrochloride salt rather than a neutral amine.
Chapter 3 Solutions
Organic Chemistry
Ch. 3 - Prob. 3.1PCh. 3 - (a) Classify the carbon atoms in each compound as...Ch. 3 - Problem 3.3 Classify a carbon atom by the number...Ch. 3 - Classify each alkyl halide and alcohol as , or...Ch. 3 - Prob. 3.5PCh. 3 - Prob. 3.6PCh. 3 - Draw the structure of a compound of molecular...Ch. 3 - Prob. 3.8PCh. 3 - Prob. 3.9PCh. 3 - Draw the structure of a compound fitting each...
Ch. 3 - Draw structures that fit each description and name...Ch. 3 - What types of intermolecular forces are present in...Ch. 3 - Which compound in each pair has the higher boiling...Ch. 3 - Explain why the boiling point of propanamide, is...Ch. 3 - Predict which compound in each pair has the higher...Ch. 3 - Prob. 3.16PCh. 3 - Which compounds are water soluble? a. b. c.Ch. 3 - a Label the hydrophobic and hydrophilic portions...Ch. 3 - Prob. 3.19PCh. 3 - Prob. 3.20PCh. 3 - Prob. 3.21PCh. 3 - Prob. 3.22PCh. 3 - Problem 3.23 (a) What types of intermolecular...Ch. 3 - Prob. 3.24PCh. 3 - Prob. 3.25PCh. 3 - Problem 3.26 Label the electrophilic and...Ch. 3 - Problem 3.27 Considering only electron density,...Ch. 3 - Prob. 3.28PCh. 3 - 3.29
Identify the functional groups in the...Ch. 3 - Prob. 3.30PCh. 3 - 3.31 For each alkane: (a) classify each carbon...Ch. 3 - 3.32 Identify the functional groups in each...Ch. 3 - 3.33 Identify each functional group located in the...Ch. 3 - 3.34 (a)Identify the functional groups in...Ch. 3 - Draw seven constitutional isomers with molecular...Ch. 3 - Prob. 3.36PCh. 3 - Prob. 3.37PCh. 3 - Prob. 3.38PCh. 3 - Intramolecular force of attraction are often...Ch. 3 - 3.40 (a) Draw four compounds with molecular...Ch. 3 - 3.41 Rank the compounds in each group in order of...Ch. 3 - Explain why CH3CH2NHCH3 has higher boiling point...Ch. 3 - Prob. 3.43PCh. 3 - 3.44 Rank the following compounds in order of...Ch. 3 - Prob. 3.45PCh. 3 - 3.46 Rank the following compounds in order of...Ch. 3 - 3.47 Which of the following molecules can hydrogen...Ch. 3 - 3.48 Explain why diethylether and have similar...Ch. 3 - Prob. 3.49PCh. 3 - 3.50 Predict the solubility of each of the...Ch. 3 - Prob. 3.51PCh. 3 - Prob. 3.52PCh. 3 - 3.53 THC is the active component in marijuana, and...Ch. 3 - Prob. 3.54PCh. 3 - Prob. 3.55PCh. 3 - 3.56 Label the electrophilic and nucleophilic...Ch. 3 - 3.57 By using only electron density arguments,...Ch. 3 - 3.58 The composition of a cell membrane is not...Ch. 3 - Prob. 3.59PCh. 3 - 3.60 Quinapril (trade name Accupril) is a drug...Ch. 3 - 3.61 Answer each question about oxycodone, a...Ch. 3 - Prob. 3.62PCh. 3 - Prob. 3.63PCh. 3 - 3.64 Explain why A is less water soluble than B,...Ch. 3 - 3.65 Recall from section 1.10B that there is...
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