Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 25, Problem 25.44CP

(a)

Interpretation Introduction

Interpretation:

Four compounds within citric acid cycle that the carbon skeletons of the glucogenic amino acid enter has to be identified.

Concept introduction:

  • The citric acid cycle includes a series of oxidation-reduction reactions in mitochondria that results in the oxidation of an acetyl group to two molecules of carbon dioxide and reduce the coenzymes that are reoxidized through the electron transport chain, linked to the formation of ATP
  • Amino acids that are converted to acetoacetylCoA or acetylCoA then enter the ketogenesis pathway are called ketogenic amino acids.
  • The amino acids that proceed by way of oxaloacetate to gluconeogenesis pathway are called glucogenic amino acids.

(b)

Interpretation Introduction

Interpretation:

Out of the four compounds, the one which arises exclusively from aromatic amino acids has to be identified.

Concept introduction:

  • The citric acid cycle includes a series of oxidation-reduction reactions in mitochondria that results in the oxidation of an acetyl group to two molecules of carbon dioxide and reduce the coenzymes that are reoxidized through the electron transport chain, linked to the formation of ATP
  • Amino acids that are converted to acetoacetylCoA or acetylCoA then enter the ketogenesis pathway are called ketogenic amino acids.
  • The amino acids that proceed by way of oxaloacetate to gluconeogenesis pathway are called glucogenic amino acids.
  • Aromatic amino acids include phenylalanine and tyrosine.

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Consider the following Statements: (1) Citric acid cycle intermediates are often the products from amino acid carbon skeleton degradation. (2) The net effect of transamination is to collect the amino groups from a variety of amino acids into the amino acids glutamate and aspartate. (3) All of the reactions of the urea cycle occur within mitochondria. how many is true
The citric acid cycle contains four 4-carbon dicarboxylic acids. (a) Name them.(b) Arrange them in order from least oxidized to mostoxidized.
The CO2 produced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. (a) How many rounds are required before 14CO2 is released if acetyl-CoA is labeled at its methyl group? (b) If acetyl-CoA is labeled with 14C at its carbonyl carbon, how many rounds of the cycle are required before 14CO2 is released?

Chapter 25 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

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