Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 25, Problem 25.22AP
Interpretation Introduction

Interpretation:

Structure of products formed from the transamination of pyruvate and oxaloacetate has to be determined.

Concept introduction:

  • Transamination of amino acid is the reaction in which amino group is converted to keto acid and formation of a new amino acid takes place.
  • The reaction is the interchange of amino group from given amino acid with the keto group from α-ketoglutarate. During transamination reaction α-ketoglutarate gives glutamate as the product. The product from the amino acid is the keto group.
  • Oxidative deamination is the removal of NH4+ bonded to αcarbon and replacing them by a C=O gives the desired α-ketoacid.

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In what condition and why is pyruvate converted to lactate?
Pyridoxal phosphate acts as an intermediate carrier of amino groups during transamination reactions. Write a series of reactions to show the role of pyridoxal phosphate in the transamination reaction involving alanine and α-ketoglutarate.
The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl‑CoA. E1E1 , E2E2 , and E3E3 are abbreviations for the enzymes of the complex. Classify the enzyme names, prosthetic groups, and reactions as E1E1 , E2E2 , or E3E3 .

Chapter 25 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

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