Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 24, Problem 8CONQ
Summary Introduction
To review:
The necessity of putting gaps while aligning two sequences and two kinds of changes resulting in the presence of gaps in multiple sequence alignment of homologous genes.
Introduction:
Alignment is the method of comparing two sequences along the same length. Alignment can reveal the percentage of similarity between the two sequences and thus, the evolutionary relatedness. When alignment is carried out between three or more than three sequences to identify conserved regions as well as the regions of similarity, it is known as multiple sequence alignment.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Explain how the different “-omics” involved with the three major parts of the central dogma can be used to study this new species. What are molecular techniques/tools (sequencers) that can be used to study each of these? How would you sequence the genome efficiently (i.e., lowest amount of time and money)?
A researcher examines genes for several proteins that are quite similar in both structure and function. He is interested in determining whether the genes form a multigene family and in working out which of the proteins arose first evolutionarily. What would be the BEST approach to take to address this question? Be careful to look for the best approach; some other approaches could also provide useful information while being less definitive.
A. The researcher should sequence the genes and compare their sequences. The most similar genes are likely the most closely related, while those that have more base differences probably diverged earlier.
B. The researcher should examine the functions of the proteins. Those with the most similar functions are the most closely related.
C. The researcher should induce mutations in the genes to see how these affect the function. The most mutations needed to cause changes in the function of the protein, the older the gene.
D. The researcher should…
A researcher examines genes for several proteins that are quite similar in both structure and function. He is interested in determining whether the genes form a multigene family and in working out which of the proteins arose first evolutionarily. What would be the BEST approach to take to address this question? Be careful to look for the best approach; some other approaches could also provide useful information while being less definitive.
A.
The researcher should sequence the genes and compare their sequences. The most similar genes are likely the most closely related, while those that have more base differences probably diverged earlier.
B.
The researcher should examine the functions of the proteins. Those with the most similar functions are the most closely related.
C.
The researcher should induce mutations in the genes to see how these affect the function. The most mutations needed to cause changes in the function of the protein, the older the gene.
D.
The…
Chapter 24 Solutions
Genetics: Analysis and Principles
Ch. 24.1 - 1. A DNA microarray is a slide that is dotted...Ch. 24.1 - 2. The purpose of a ChIP-chip assay is to...Ch. 24.1 - 3. For the method of RNA sequencing (RNA-Seq),...Ch. 24.1 - A gene knockout is a gene a. whose function has...Ch. 24.2 - Prob. 1COMQCh. 24.2 - Prob. 2COMQCh. 24.2 - Prob. 3COMQCh. 24.2 - Prob. 4COMQCh. 24.3 - Prob. 1COMQCh. 24.3 - 2. Homologous genes
a. are derived from the same...
Ch. 24.3 - Prob. 3COMQCh. 24 - 1. Give the meanings of the following terms:...Ch. 24 - Prob. 2CONQCh. 24 - What is a database? What types of information are...Ch. 24 - Prob. 4CONQCh. 24 - Prob. 5CONQCh. 24 - Prob. 6CONQCh. 24 - Prob. 7CONQCh. 24 - Prob. 8CONQCh. 24 - Prob. 1EQCh. 24 - In the procedure called RNA sequencing (RNA-Seq),...Ch. 24 - 3. Can two-dimensional gel electrophoresis be used...Ch. 24 - Prob. 4EQCh. 24 - 5. Describe the two general types of protein...Ch. 24 - 6. Discuss the bioinformatics approaches that can...Ch. 24 - 7. What is a motif? Why is it useful for computer...Ch. 24 - Discuss why it is useful to search a database to...Ch. 24 - Prob. 9EQCh. 24 - In this chapter, we considered a computer program...Ch. 24 - Prob. 11EQCh. 24 - Prob. 12EQCh. 24 - Prob. 13EQCh. 24 - Refer to question 3 in More Genetic TIPS before...Ch. 24 - Prob. 15EQCh. 24 - Prob. 16EQCh. 24 - 1. Let’s suppose you are in charge of organizing...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- An ancestral gene "Stacin" is involved in initiating parental care in both males and females. The stacin gene duplicates and mutations arise in both copies that change the function. One copy becomes specialized to function in male parental care "Patristacin" and the other copy becomes specialized to function in female parental care "Matristacin". Which of the following terms best describes this change in function in the two sequences? Group of answer choices Profunctionalization Prefunctionalization Subfunctionalization Neofunctionalizationarrow_forwardWhen comparing evolutionary similarities between different genes within a gene family, it is usually more straightforward to compare genes by using the protein sequences of gene products rather than DNA sequences of the genes themselves. Explain why this is the case. (Write 5 points)arrow_forwardBioinformatics is an interdisciplinary field that integrates computer science with mathematics and statistics to solve biological questions. Many bioinformatic tools for gene prediction, homology modelling and such are available free online. State the functions of CLUSTAL W, BLAST and GLIDE (Schrödinger).arrow_forward
- In genomes the potential duplicate/paralog share the same annotation but have lower sequence similiarity. Discuss what could have caused this difference and its possible driver.arrow_forwardBioinformatics is an interdisciplinary field that integrates knowledge of computer science with mathematics and statistics to solve biological questions. Many bioinformatics tools for gene prediction, homology modelling and such are available free online. (1) What does BLAST stand for? (ii) Explain the function of BLAST.arrow_forwardDescribe the mutation that created the HBs allele: type of mutation, location of mutation on HbA sequence (#of bases from beginning of sequence), nucleotide change (from which base to which base?) Also mention the reputable published source to support this informationarrow_forward
- Here is some information about the sequences: There are two images given; one with sequences and the other with a figure. All these sequences, “SEQUENCE_21” to “SEQUENCE_27” are in the same subfamily or “clade” of a large phylogenetic alignment of all Rab proteins in these three species (see “Image with a figure” for a full view of gene family in humans, plants and yeast, see the “D” branch towards the bottom of the tree in Figure). “SEQUENCE_28” is a different Rab protein (actually it is the Rab39 protein at the bottom of the tree). “SEQUENCE_21” is from yeast. “SEQUENCE_22” to “SEQUENCE_25” are from the plant, Arabidopsis. “SEQUENCE_26” and “SEQUENCE_27” are from humans. Question: Based on the information above, what can you speculate about the possible evolution of the genes that “SEQUENCE_21” to “SEQUENCE_27” represent?arrow_forwardIf you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome.arrow_forwardDiscuss why it is useful to search a database to identify sequencesthat are homologous to a newly determined sequence.arrow_forward
- Should similarities in the DNA sequences of genes be considered evolutionary homology? Explain.arrow_forwardWrite a paragraph describing the evolutionary forces driving changes in the human genome. You can include evolutionary forces such as random genetic drift, mutation, migration, and natural selection. These forces would have long-term and short-term effects on coding and non-coding DNA, the abundance of transposable elements, and the birth and death of genes. You can focus on a subset of the human population, or the entire species.arrow_forwardThis question refers to the following table, which compares the percent sequence homology of four different parts (two introns and two exons) of a gene that is found in five different eukaryotic species. Each part is numbered to indicate its distance from the promoter (e.g., Intron I is the one closest to the promoter). The data reported for species A were obtained by comparing DNA from one member of species A to another member of species A. % Sequence Homology Species Intron I Exon I Intron VI Exon VI A 100 100 100 100 В 98 99 82 96 C 98 99 89 96 D 99 99 92 97 E 98 99 80 94 Which of these four gene parts should allow the construction of the most accurate phylogenetic tree, assuming that this is the only part of the gene that has acted as a reliable molecular clock? Intron VI Exon I Exon VI Intron Iarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Genome Annotation, Sequence Conventions and Reading Frames; Author: Loren Launen;https://www.youtube.com/watch?v=MWvYgGyqVys;License: Standard Youtube License