Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 24, Problem 24.29AP
Interpretation Introduction

Interpretation:

The transformation which is necessary to convert glyceraldehyde-3-phosphate into pyruvate should be determined.

Concept introduction:

β-oxidation is the oxidation and splitting of two carbon units at β- carbon atom. This results in sequential removal of 2 carbon fragments as acetyl CoA until the complete oxidation of fatty acids.

Glycolysis: This is the metabolic process that serves as the foundation for both aerobic and anaerobic cellular respiration, in glycolysis, glucose is converted into pyruvate. Glucose is a six-membered ring molecule found in the blood and is usually a result of the breakdown of carbohydrates into sugars. It enters cells though specific transporter proteins that moves it from outside the cell into the cell cytosol.

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Trace the pathway of [1-14C]pyruvate through gluconeogenesis. Use an asterisk to indicate the location of 14C in all intermediates and in the final gluconeogenesis product, glucose. CH₂ -C=0 Coo [1-1C]Pyruvate CH,OPO H-C-OH C-OPO || 1,3-Bisphospho- glycerate ↑ -coo -CH₂ KC=0 -Coo Oxaloacetate CH,OPO H-C-OH COO 3-Phosphoglycerate CH₂ -OPO OP COO Phosphoenolpyruvate CH,OH H-C-OPO COO 2-Phosphoglycerate
Phosphoglycerate mutase (PGM) catalyzes the interconversion of 3-phosphoglycerate (3PG) and 2-phosphoglycerate (2PG) in the glycolytic and gluconeogenic pathways. a) To what enzyme class does PGM belong?   b) There are two distinct classes of PGM, one which is dependent on 2,3-bisphosphoglycerate (2,3-BPG), dPGM, and one which is not, iPGM. dPGM uses acid base chemistry and a phosphorylated histidine residue to interconvert 3PG and 2PG. The dPGM reaction proceeds with formation of 2,3-BPG as an intermediate. Propose a mechanism for the dPGM-catalyzed conversion of 3PG to 2PG that is consistent with this information.   c) What is the purpose of 2,3-BPG (i.e., why does dPGM require it)?

Chapter 24 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

Ch. 24.6 - Prob. 24.8PCh. 24.6 - Prob. 24.9PCh. 24.7 - Prob. 24.4CIAPCh. 24.7 - Prob. 24.5CIAPCh. 24.7 - Prob. 24.6CIAPCh. 24.7 - What is atherosclerosis?Ch. 24.7 - Prob. 24.8CIAPCh. 24 - Oxygen is not a reactant in the oxidation of...Ch. 24 - Prob. 24.12UKCCh. 24 - Prob. 24.13UKCCh. 24 - Prob. 24.14UKCCh. 24 - Prob. 24.15UKCCh. 24 - Prob. 24.16UKCCh. 24 - Prob. 24.17UKCCh. 24 - Prob. 24.18UKCCh. 24 - Prob. 24.19APCh. 24 - Prob. 24.20APCh. 24 - Prob. 24.21APCh. 24 - Prob. 24.22APCh. 24 - Prob. 24.23APCh. 24 - Prob. 24.24APCh. 24 - Prob. 24.25APCh. 24 - Prob. 24.26APCh. 24 - Prob. 24.27APCh. 24 - Prob. 24.28APCh. 24 - Prob. 24.29APCh. 24 - Prob. 24.30APCh. 24 - Prob. 24.33APCh. 24 - Prob. 24.34APCh. 24 - Prob. 24.35APCh. 24 - Prob. 24.36APCh. 24 - Prob. 24.37APCh. 24 - Prob. 24.38APCh. 24 - Prob. 24.39APCh. 24 - Prob. 24.40APCh. 24 - Prob. 24.41APCh. 24 - Prob. 24.42APCh. 24 - Prob. 24.43APCh. 24 - Prob. 24.44APCh. 24 - Prob. 24.45APCh. 24 - Prob. 24.46APCh. 24 - Prob. 24.47APCh. 24 - Prob. 24.48APCh. 24 - Prob. 24.49APCh. 24 - Prob. 24.50APCh. 24 - Prob. 24.51APCh. 24 - Prob. 24.52APCh. 24 - Prob. 24.53APCh. 24 - Individuals suffering from ketoacidosis have...Ch. 24 - Prob. 24.55APCh. 24 - Prob. 24.56APCh. 24 - Prob. 24.57APCh. 24 - Prob. 24.58APCh. 24 - Why are fatty acids generally composed of an even...Ch. 24 - Prob. 24.60APCh. 24 - Prob. 24.62APCh. 24 - Prob. 24.63APCh. 24 - Prob. 24.64CPCh. 24 - Prob. 24.66CPCh. 24 - Prob. 24.67CPCh. 24 - Prob. 24.68CPCh. 24 - Prob. 24.70GPCh. 24 - In the synthesis of cholesterol, acetyl-CoA is...Ch. 24 - Prob. 24.72GP
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