Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 23.2, Problem 2CC
Summary Introduction

To determine: The hormone for which androstenedione is a prohormone. and the advantage of this prohormone for an athlete.

Introduction: Sex hormones are secreted by the inner portion of the adrenal cortex. These hormones are testosterone in males and estrogen in females. The major hormones secreted by the inner portion of the adrenal cortex are androgens.

Summary Introduction

To determine: The advantage of this prohormone for an athlete.

Introduction: Androgens are sex hormones that are dominant in males. Sex hormones are steroid hormones and begin their synthesis with cholesterol.

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Bodybuilders use a variety of anabolic substances to gain mass. Two such compounds are insulin and trenbolone. Insulin has significant anabolic and anti-catabolic properties and impacts the metabolism of various macromolecules, not just that of carbohydrates. Trenbolone binds the androgen receptor with an affinity five times higher than that of testosterone and is popular for its fat-burning and anabolic properties. H. Trenbolone C18H2202 Insulin C257H383NosO77S6 How do the different targets, mechanisms of action and durations of each drug ultimately lead to the same desired effect (increase in lean body mass)?
The synthetic pathways for many steroid hormones are shown in Fig. 23-1 in Silverthorn. This Is shown in a simplified format below with several intermedlate steps omitted. Cholesterol Progesterone Andro- Testosterone Dihydro- stenedione testosterone 21-hydroxylase Estradiol Aldosterone and cortisol Aldosterone is an important steroid hormone that regulates water and salt balance. People with congenital adrenal hyperplasia suffer from "salt wasting" if not treated with hormone replacement therapy. Explain why a mutation in the 21-hydroxylase gene results in a deficiency in aldosterone and cortisol production. Use the name of the substrate, the enzyme and the product in your answer!
Look at the structures of the three female sex hormones shown on page 867. Identify the type of functional group change that interconverts estradiol and estrone. To which class of chemical reactions does this change belong?
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