Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 23, Problem 10RQ
Summary Introduction
To determine: The time taken by T3 to generate a response in the tissues.
Introduction: Hormones are chemical messengers which transport the signal from a particular location to target location. These are secreted in the blood. Hormones are specifically involved in long-distance transport of signals.
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Which of the following observations can be explained by the properties of hormone receptors?
a) A certain tissue can react to more than one hormone
b) A certain hormone affects only a specific tissue, not all tissues
c) Some tissues react very quickly to a certain hormone, other tissues take many hours to react to the same hormone
Suppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).
Which statement correctly identifies how a lipid-soluble hormone that diffuses from the blood and through the interstitial fluid
identifies which cells in the tissue to act upon?
O The cell closest to the diffusion site.
O The presence of a receptor located in the cytoplasm or nucleus specific to the hormone in cells.
O The presence of a receptor embedded in the plasma membrane of target cells.
O The presence of a channel protein embedded in the plasma membrane for the lipid-soluble hormone to diffuse through.
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Chapter 23 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 23.2 - Prob. 1CCCh. 23.2 - Prob. 2CCCh. 23.2 - What do the abbreviations HPA and CBG stand for?...Ch. 23.2 - Prob. 4CCCh. 23.2 - Prob. 5CCCh. 23.2 - Prob. 6CCCh. 23.2 - Would someone with Addisons disease have normal,...Ch. 23.2 - Prob. 8CCCh. 23.3 - A woman who had her thyroid gland removed because...Ch. 23.3 - Prob. 10CC
Ch. 23.4 - Prob. 11CCCh. 23.5 - Prob. 12CCCh. 23.5 - Prob. 13CCCh. 23.6 - Prob. 14CCCh. 23.6 - Prob. 15CCCh. 23.6 - Prob. 16CCCh. 23.6 - Prob. 17CCCh. 23 - Name the zones of the adrenal cortex and the...Ch. 23 - For (a) cortisol, (b) growth hormone, (c)...Ch. 23 - Prob. 3RQCh. 23 - Prob. 4RQCh. 23 - Define each of the following terms and explain its...Ch. 23 - Prob. 6RQCh. 23 - Prob. 7RQCh. 23 - Prob. 8RQCh. 23 - Define, compare, and contrast or relate the terms...Ch. 23 - Prob. 10RQCh. 23 - Prob. 11RQCh. 23 - Osteoclasts make acid (H+) from CO2 and H2O. They...Ch. 23 - Prob. 13RQCh. 23 - One diagnostic test to determine the cause of...Ch. 23 - Prob. 15RQCh. 23 - Prob. 16RQCh. 23 - Prob. 17RQCh. 23 - Prob. 18RQCh. 23 - Prob. 19RQ
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- Please identify the incorrect statement about hormone signaling: A) Cystolic receptors bind to hydophobic hormones and transport them into the nucleus where they directly influence protein synthesis. B) Hydropholic hormones cannot pass through the plasma membrane without help. Therefore, there are transport proteins that carry the hydrophillic hormones to the cytosol where it can bind its receptor C) Hydrophilic hormone signalling involves membrane receptors that have the ability to activate adenylyl cyclase, producing cAMP. cAMP then affects the activity of numerous proteins in the cytoplam. D) Hydrophobic hormones easily enter the plasma membrane. Therefore, there is no need for hydrophinic hormone receptors to be on the extracellular surface.arrow_forwardOverexpression of this receptor in the cells of the adrenal gland causes Cushing's syndrome, a disease caused by the overproduction of cortisol. One strategy that scientists have employed to treat this disease is the use of small molecules that bind to, but do not activate, MC2R. This type of molecule is generically referred to as an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it? O a. The antagonist can bind covalently while ACTH binds non-covalently O b. The antagonist is only partially complimentary to the binding pocket of MC2R O The antagonist binds to ACTH and blocks it from binding to the receptor properly O d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn't work One cause of Cushing's syndrome is the inappropriate production of GPCRS in the adrenal gland that are not normally present in those cells. When these receptors are activated they result in the production of cortisol. Which statement about…arrow_forwardHormone release and regulation is a complex interplay of control systems, feedback pathways and the concentration of circulating substances. Demonstrate your understanding of how negative feedback systems work by considering what would happen if the usual mechanisms no longer applied. You may like to think about an ectopic source of adrenocorticotropic hormone (ACTH), as secreted from a small cell carcinoma of the lung, as an example. In your explanation of how negative feedback systems can be derailed, describe how hormone/s released from the target endocrine organ usually regulate the feedback loop.arrow_forward
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