Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 24ESP
Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development.
- (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer.
- (b) What evidence indicates that the eyeless gene is part of a developmental network?
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Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network?
provide one example from the Drosophila AP toolkit for "Toolkit genes can be classified according to the phenotypes caused by their mutation. Similar mutant phenotypes often reflect genes that function in a single developmental pathway. Distinct pathways exist for the generation of body axes, for example, and for the formation and identity of fields."
It seems that developmental genetics boils down to a complex network of gene regulation. Try to draw a structure of this network for Drosophila. How many genes do you think are necessary to complete the developmental network for the fruit fly? How many genes do you think are needed for a network to specify one segment? Do you think it is more difficult to identify genes that are involved in the beginning, middle, or end of this network? Suppose you were trying to identify all of the genes needed for development in a chicken. Knowing what you know about Drosophila development, would you first try to identify genes necessary for early development, or would you begin by identifying genes involved in cell differentiation?
Chapter 23 Solutions
Concepts of Genetics (12th Edition)
Ch. 23 - Suppose you initiate a screen for maternal-effect...Ch. 23 - Prob. 2NSTCh. 23 - Prob. 1CSCh. 23 - Prob. 2CSCh. 23 - Prob. 1PDQCh. 23 - Prob. 2PDQCh. 23 - Prob. 3PDQCh. 23 - Nuclei from almost any source may be injected into...Ch. 23 - Distinguish between the syncytial blastoderm stage...Ch. 23 - Prob. 6PDQ
Ch. 23 - Prob. 7PDQCh. 23 - List the main classes of zygotic genes. What is...Ch. 23 - Experiments have shown that any nuclei placed in...Ch. 23 - Prob. 10PDQCh. 23 - Prob. 11PDQCh. 23 - Prob. 12PDQCh. 23 - Prob. 13PDQCh. 23 - Prob. 14PDQCh. 23 - Prob. 15PDQCh. 23 - Prob. 16PDQCh. 23 - Prob. 17PDQCh. 23 - A number of genes that control expression of Hox...Ch. 23 - The apterous gene in Drosophila encodes a protein...Ch. 23 - In Arabidopsis, flower development is controlled...Ch. 23 - Prob. 21ESPCh. 23 - Prob. 22ESPCh. 23 - Much of what we know about gene interactions in...Ch. 23 - Dominguez et al. (2004) suggest that by studying...
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- Name three possible factors contributing to early asymmetries in a developing embryo (i.e. what are the kinds of things early on that lead to the development of the body axes - dn, a/p, l/r, etc)? In the fruit fly drosophila melanogaster, the anterior-to-posterior body axis becomes segmented into distinct regions. explain the role of the genes bicoid and nanos in this process.arrow_forwardThe anterior–posterior axis of a Drosophila embryo is first established by certain (a) homeotic genes (b) maternal effect genes (c) segmentation genes (d) proto-oncogenes (e) pair–rule genesarrow_forwardWhat is positional information? What are three different ways that cells obtain positional information? Which of these ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forward
- You discover a new Drosophila mutant in which mouthparts are located where the antennae are normally found. You predict that the mutated gene is most likely a (a) homeotic gene (b) gap gene (c) pair–rule gene (d) maternal effect gene (e) segment polarity genearrow_forwardChristiane Nüsslein-Volhard and her colleagues carried out several experiments in an attempt to understand what determines the anterior and posterior ends of a Drosophila larva (reviewed in C. NüssleinVolhard, H. G. Frohnhofer, and R. Lehmann. 1987. Science 238:1675– 1681). They isolated fruit flies with mutations in the bicoid gene (bcd−). These flies produced embryos that lacked a head and thorax. When they transplanted cytoplasm from the anterior end of an egg from a wild-type female into the anterior end of an egg from a mutant bicoid female, normal head and thorax development took place in the embryo. However, transplanting cytoplasm from the posterior end of an egg from a wild-type female into the anterior end of an egg from a bicoid femalehad no effect. Explain these results in regard to what you know about proteins that control the determination of the anterior–posterior axis.arrow_forwardChristiane Nüsslein-Volhard and her colleagues carried out several experiments in an attempt to understand what determines the anterior and posterior ends of a Drosophila larva (reviewed in C. Nüsslein- Volhard, H. G. Frohnhofer, and R. Lehmann. 1987. Science 238:1675– 1681). They isolated fruit flies with mutations in the bicoid gene (bcd−). These flies produced embryos that lacked a head and thorax. When they transplanted cytoplasm from the anterior end of an egg from a wild-type female into the anterior end of an egg from a mutant bicoid female, normal head and thorax development took place in the embryo. However, transplanting cytoplasm from the posterior end of an egg from a wild-type female into the anterior end of an egg from a bicoid female had no effect. Explain these results in regard to what you know about proteins that control the determination of the anterior–posterior axis.arrow_forward
- Homeotic genes(A) encode transcription factors that control the expression ofgenes responsible for specific anatomical structures.(B) are found only in Drosophila and other arthropods.(C) are the only genes that contain the homeobox domain.(D) encode proteins that form anatomical structures in the fly.arrow_forwardYou isolate a glp-1 mutation of C. elegans and discover that the DNA region encoding the spatial control region (SCR) has been deleted. What will the GLP-1 protein expression pattern be in a four-cell embryo in mutant heterozygotes? In mutant homozygotes?arrow_forwardWhich of the following illustrates the regulative nature of early mouse development? (a) the mouse embryo is freeliving prior to implantation in the uterus (b) it is possible to produce a transgenic mouse (c) it is possible to produce a mouse in which a specific gene has been knocked out(d) genes related to Drosophila homeotic genes have been identified in mice (e) a chimeric mouse can be produced by fusing two mouse embryosarrow_forward
- Compare and contrast the experimental advantages and disadvantages of Drosophila, C. elegans, mammals, and Arabidopsis.arrow_forwardWhat are the relative merits of Drosophila, C. elegans, M. musculus, and Arabidopsis as model organisms for the study of development?arrow_forwardHow have we discovered that specific genes control development in an organism like Drosophila?arrow_forward
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