Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 2NST
Summary Introduction
To determine: The inferences about the regulation of ftz and eng genes.
Introduction: In Drosophila, fushi tarazu (ftz) and engrailed (eng) genes encode homeobox transcription factors. These two genes are capable of eliciting the expression of other genes. Both genes work at the same time during development and in the same region.
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The floral homeotic genes of Arabidopsis belong to the MADS-box gene family, while in Drosophila, homeotic genes belong to the homeobox gene family. In both Arabidopsis and Drosophila, members of the Polycomb gene family control expression of these divergent homeotic genes. How do Polycomb genes control expression of two very different sets of homeotic genes?
A mutation occurs in the Drosophila doublesex gene that prevents Tra from binding to the dsx RNA transcript. What would be the consequences of this mutation for Dsx protein expression in males? In females?
Progesterone is a steroid hormone (also described as a ligand) that prepares the body
for pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm of
various cells.
Ligand bound PR acts as a transcriptional activator, binds to the DNA in the
promoter region of several genes and leads to transcriptional activation of these
genes.
Ligand bound PR has been shown to increase the expression of a gene, FKBP5.
You are studying the activity of wild-type (WT) and mutant PR in cells by examining
expression of FKBP5. Results are obtained as shown in the figure below, where the
asterisk indicates when progesterone was (or was not) added to the cells.
From the results, which of the following statements can be concluded?
WT PR without progesterone
WT PR with progesterone
Time
Time
mutant PR without progesterone
mutant PR with progesterone
Time
Time
The wild-type PR is unable to increase FKBP5 expression in the absence of
ligand
The wild-type PR increases FKBP5 expression after…
Chapter 23 Solutions
Concepts of Genetics (12th Edition)
Ch. 23 - Suppose you initiate a screen for maternal-effect...Ch. 23 - Prob. 2NSTCh. 23 - Prob. 1CSCh. 23 - Prob. 2CSCh. 23 - Prob. 1PDQCh. 23 - Prob. 2PDQCh. 23 - Prob. 3PDQCh. 23 - Nuclei from almost any source may be injected into...Ch. 23 - Distinguish between the syncytial blastoderm stage...Ch. 23 - Prob. 6PDQ
Ch. 23 - Prob. 7PDQCh. 23 - List the main classes of zygotic genes. What is...Ch. 23 - Experiments have shown that any nuclei placed in...Ch. 23 - Prob. 10PDQCh. 23 - Prob. 11PDQCh. 23 - Prob. 12PDQCh. 23 - Prob. 13PDQCh. 23 - Prob. 14PDQCh. 23 - Prob. 15PDQCh. 23 - Prob. 16PDQCh. 23 - Prob. 17PDQCh. 23 - A number of genes that control expression of Hox...Ch. 23 - The apterous gene in Drosophila encodes a protein...Ch. 23 - In Arabidopsis, flower development is controlled...Ch. 23 - Prob. 21ESPCh. 23 - Prob. 22ESPCh. 23 - Much of what we know about gene interactions in...Ch. 23 - Dominguez et al. (2004) suggest that by studying...
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- Progesterone is a steroid hormone (also described as a ligand) that prepares the body for pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm of various cells. Ligand bound PR acts as a transcriptional activator, binds to the DNA in the promoter region of several genes and leads to transcriptional activation of these genes. Which of the following statements must be true for the PR protein? O Ligand binding to the PR results in a conformational change in the primary structure of the protein The domain/region of the PR protein that interacts with the DNA, has basic amino acids Ligand binding to the PR results in a conformational change in the tertiary structure of the protein The domain/region of the PR protein that interacts with the DNA, has acidic amino acidsarrow_forwardHelp me pleasearrow_forwardDiscuss the morphological differences between the parasegments and segments of Drosophila. Discuss the evidence, providing specific examples, that suggests the parasegments of the embryo are the subdivisions for the organization of gene expression.arrow_forward
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