Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 13PDQ
Summary Introduction
To determine: The insight shared by spineless aristapedia (ssa) mutation regarding the function of genes during determination.
Introduction: Determination refers to the establishment of a specific pattern of gene activity and developmental fate for a given cell. It usually occurs before any manifestation of the cell’s future
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Discuss the morphological differences between the parasegments and segments of Drosophila. Discuss the evidence, providing specific examples, that suggests the parasegments of the embryo are the subdivisions for the organization of gene expression.
Suppose a researcher has three different Drosophila strains that have mutations in the bicoid gene called bicoid-A, bicoid-B, and bicoid-C; the wild type is designated bicoid +. To study these mutations,
phenotypically normal female flies that are homozygous for the given bicoid mutation were obtained, and their oocytes were analyzed using a Northern blot to determine the size and/or amount of the bicoid
mRNA and in situ hybridization to determine the bicoid mRNA location within the oocyte. A wild-type strain was also analyzed as a control. In both cases, the probe was complementary to the bicoid mRNA and
the results are shown below. (Anterior is on the left; posterior is on the right.)
Northern blot
1
2
-
3 4
In situ hybridization
Wild type
Lane 1. Wild type (bicoid*)
Lane 2. bicoid-A
Lane 3. bicoid-B
Lane 4. bicoid-C
bicoid-B
bicoid-A
bicoid-C
Which mutation is likely to cause the embryo to develop two "anterior" ends?
bicoid-B
Obicoid-A
bicoid-C
) Explain how and why dorsal/ventral polarity will be affected in fly
Question 3 (1.
embryos carrying the following mutations; also in each case darken in the area of the cells
in the cross-sectional view of the fly embryo which are expected to express the paulie gene.
D = dorsal; V = ventral.
a) a mutation which results in the deletion of the cytoplasmic domain of the Cookie protein.
b) A mutation which results in a constitutively active Bombe protein, i.e. the Bombe protein
is always in an activated state.
c) A mutation which causes the Pickle protein to be retained in the cytoplasm of the
embryo.
Chapter 23 Solutions
Concepts of Genetics (12th Edition)
Ch. 23 - Suppose you initiate a screen for maternal-effect...Ch. 23 - Prob. 2NSTCh. 23 - Prob. 1CSCh. 23 - Prob. 2CSCh. 23 - Prob. 1PDQCh. 23 - Prob. 2PDQCh. 23 - Prob. 3PDQCh. 23 - Nuclei from almost any source may be injected into...Ch. 23 - Distinguish between the syncytial blastoderm stage...Ch. 23 - Prob. 6PDQ
Ch. 23 - Prob. 7PDQCh. 23 - List the main classes of zygotic genes. What is...Ch. 23 - Experiments have shown that any nuclei placed in...Ch. 23 - Prob. 10PDQCh. 23 - Prob. 11PDQCh. 23 - Prob. 12PDQCh. 23 - Prob. 13PDQCh. 23 - Prob. 14PDQCh. 23 - Prob. 15PDQCh. 23 - Prob. 16PDQCh. 23 - Prob. 17PDQCh. 23 - A number of genes that control expression of Hox...Ch. 23 - The apterous gene in Drosophila encodes a protein...Ch. 23 - In Arabidopsis, flower development is controlled...Ch. 23 - Prob. 21ESPCh. 23 - Prob. 22ESPCh. 23 - Much of what we know about gene interactions in...Ch. 23 - Dominguez et al. (2004) suggest that by studying...
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