Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 22.2, Problem 5CC
Summary Introduction

To determine: A complete balanced equation of aerobic metabolism of one molecule of glucose.

Introduction: The metabolic pathway which yields lactic acid or pyruvate from the glucose molecule is known as glycolysis. The product obtained from the process of glycolysis is based on the presence or absence of oxygen.

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The glucose/glucose-6-phosphate substrate cycle involves distinct reactions of glycolysis and gluconeogenesis that interconvert these two metabolites. Assume that under physiological conditions, [ATP] = [ADP]; [P;] = 1 mM. Consider the glycolytic reaction catalyzed by hexokinase: ATP + glucose ADP + glucose-6-phosphate AG = - 16.7 kJ/mol (a) Calculate the equilibrium constant (K) for this reaction at 298°K, and from that, calculate the maximum [glucose-6-phosphate]/ Iglucose] ratio that would exist under conditions where the reaction is still thermodynamically favorable. (b) Reversal of this interconversion in gluconeogenesis is catalyzed by glucose-6-phosphatase: glucose-6-phosphate + H20 = glucose + P AG" = -13.8 kJ/mol
Consider ten glucose molecules that enter a cell. How many ATP can be generated by the complete catabolism of these into CO2 and H2O? If all ten are first incorporated into glycogen, liberated from glycogen, and then fully catabolized into CO2 and H2O, does the ATP tally increase, decrease or stay the same? Consider that 1 UTP = 1 ATP. Explain. Describe the processes which produce ATP and provide a balanced equation of glucose, CO2, H2O and O2
Which of the following is the correct summary of phase II of glycolysis for each molecule of glucose?   Glucose + ATP ⟶ Glyceraldehy-3-phosphate + ADP   Glucose + 2 ATP ⟶ 2(Glyceraldehy-3-phosphate) + 2 ADP   Glyceraldehyde-3-phosphate + NAD+ + ADP + Pi ⟶ 3-phosphoglycerate + NADH + H+ + ATP   2(3-phosphoglycerate) + 2ADP ⟶ 2 pyruvate + 2ATP   2(Glyceraldehyde-3-phosphate) + 2NAD+ + 2ADP + 2Pi ⟶ 2(3-phosphoglycerate) + 2NADH + 2H+ + 2ATP

Chapter 22 Solutions

Human Physiology: An Integrated Approach (8th Edition)

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