Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 22, Problem 21ESP
Following the tragic shooting of 20 children at a school in Newtown, Connecticut, in 2012, Connecticut’s state medical examiner requested a full genetic analysis of the killer’s genome. What do you think investigators might be looking for? What might they expect to find? Might this analysis lead to oversimplified analysis of the cause of the tragedy?
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Following the tragic shooting of 20 children at a school in Newtown, Connecticut, in 2012, Connecticut’s state medical examiner requested a full genetic analysis of the killer’s genome. What do you think investigators might be looking for? What might they expect to find? Might this analysis lead to oversimplified analysis of the cause of the tragedy?
1. a) If you were at risk of a fatal disease such as Huntington’s disease and only the 95% accurate preliminary genetic test was available, would you take the test? After all, 95% of the time the test would tell you whether you would eventually get Huntington’s disease or whether you did not have to worry about getting this disease.
b) The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?
Pick one (1) of the five (5) principles developed by the Ethics Committee for the Human Genome Organization that must be considered when the global community is confronted by new technology. Why do you feel that principle is MOST important.
Chapter 22 Solutions
Concepts of Genetics (12th Edition)
Ch. 22 - In order to vaccinate people against diseases by...Ch. 22 - Prob. 2NSTCh. 22 - Prob. 1CSCh. 22 - Prob. 2CSCh. 22 - Prob. 3CSCh. 22 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 22 - Prob. 2PDQCh. 22 - Why are most recombinant human proteins produced...Ch. 22 - One of the major causes of sickness, death, and...Ch. 22 - Sequencing the human genome, the development of...
Ch. 22 - Prob. 6PDQCh. 22 - As genetic testing becomes widespread, medical...Ch. 22 - Prob. 8PDQCh. 22 - Prob. 9PDQCh. 22 - Does genetic analysis by ASO testing allow for...Ch. 22 - Maternal blood tests for three pregnant women...Ch. 22 - What is the main purpose of genome-wide...Ch. 22 - Describe how the team from the J. Craig Venter...Ch. 22 - Prob. 14PDQCh. 22 - Prob. 15PDQCh. 22 - Dominant mutations can be categorized according to...Ch. 22 - In 2013 the actress Angelina Jolie elected to have...Ch. 22 - Prob. 18PDQCh. 22 - Should the FDA regulate direct-to-consumer genetic...Ch. 22 - Prob. 20ESPCh. 22 - Following the tragic shooting of 20 children at a...Ch. 22 - Private companies are offering personal DNA...Ch. 22 - Prob. 23ESPCh. 22 - Prob. 24ESPCh. 22 - Prob. 25ESPCh. 22 - Craig Venter and others have constructed synthetic...
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- A 45-year-old woman undergoes genetic testing and discovers that she is at high risk for developing colon cancer and Alzheimer disease. Because her children have 50% of her genes, they may also be at an increased risk for these diseases. Does she have a moral or legal obligation to tell her children and other close relatives about the results of her genetic testing?arrow_forwardMr. I. M. Megabucks, the wealthiest man in the world, recently died. Since his death, three women have come forward. Each woman claims to have a child by Megabucks and demands a substantial share of his estate for her child. Lawyers for the estate have insisted on DNA typing of each of the alleged heirs. Fortunately, Megabucks anticipated trouble like this before he died, and he arranged to have a sample of his blood frozen for DNA typing. The results of the typing are shown in the figure below. Your job is to analyze the data and determine whether any of the children could be Megabucks' heir. Remember that every person has two of each chromosome, one inherited from his mother and one inherited from his father. Half of every person's DNA comes from his mother, and half comes from his father, so some of the DNA bands showing in the children will come from their mothers, and the rest will come from their fathers. The question is, could that father be Megabucks? For the first child,…arrow_forwardBy the time this book is published, it will likely be possible for you to obtain the sequence of your genome at nominal cost. Do you want this information? Explain the factors that affected your decision.arrow_forward
- Describe, explain and elaborate down syndrome and genetic technologies are being utilized towards the said genetic disorder. It must include the following: (1) Good introduction; (2) Description or problem of Down Syndrome; (3) Genetic technology applied with the Down Syndrome; (4) Results or benefits; (5) Risks or issues involved; and (6) Conclusion with a good ending statement.arrow_forwardWhat is DNA phenotyping, and how do law enforcement agencies use this profiling method?arrow_forwardIt has been suggested that it would make the study of human diseases easier if cloned transgenic animals were produced that carried faulty versions of human genes (e.g., the gene that causes cystic fibrosis). a. Why would such animals be useful in medical research? : b. What ethical questions are raised by the creation of such transgenic animals?arrow_forward
- What are some possible reasons that researchers might be interested in identifying the gene that causes a genetic disease such as ICA? In other words, what benefits might result from this research?arrow_forwardWhat cause of the genetic disease site your sources provide links to the websites to use?arrow_forwardIn the 1970s, scientists realized that there may be unforeseen dangers and ethical issues with the use of recombinant DNA technology. A self-imposed moratorium on related research was implemented to develop safety protocols. As the Human Genome Project, designed to sequence and analyze the DNA of the human genome, came into existence in 1990, it was accompanied by the Ethical, Legal, and Social Implications (ELSI) program. ELSI was charged with identifying and addressing issues arising from genomic research. This program focused mainly on privacy issues, the ethical use of genetic technology in medicine, and the design and conduct of genetic research, including gene therapy. The program led to the passage of federal legislation regulating the use of genetic information, and instituting guidelines limiting the scope of gene therapy. These guidelines prohibit germ-line therapy, which impact future generations, and also prohibit gene therapy designed to enhance physical or mental…arrow_forward
- Listed below are 4 of the 13 genome sites used to create a standard DNA profile. Each site consists of a number of short tandem repeats: sets of 4 nucleotides repeated in a row within the genome. For each site, the number of repeats found at that site for this individual are listed: Imagine you perform a PCR procedure to create a DNA profile for this individual. Which of the following four gels correctly represents the DNA profile of this person?arrow_forwardWhy was sequencing the human genome such a formidable task?arrow_forwardDNA dragnets have been so successful that some people have suggested that DNA samples of everyone should be stored at birth, so a profile could be made for anyone at any time. A. Do you think this is a good idea or not? And, B. do you think it useful or ethical for the FBI to store DNA samples from people who have been arrested but not yet convicted of a crime? Answer both questions,arrow_forward
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