Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 22, Problem 25ESP
Summary Introduction
To determine: The reason due to which mouse did not show lung congestion symptoms of cystic fibrosis.
Introduction: Cystic fibrosis (CF) is an autosomal recessive disease. The disease condition would appear only when an individual has a homozygous recessive (aa) gene for this disorder. This condition causes respiratory tract problems in case of human beings.
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Flow cytometry analysis was performed on the blood of an individual known to have been recently exposed to both rhinovirus (RV) and Mycobacterium tuberculosis (M.tb; an intracellular bacterial pathogen). Although an effective T cell response against RV was detected, a T cell response against M.tb was absent. Subsequently, genetic testing was performed, and the individual was found to possess two mutations. Below, indicate the MOST LIKELY mutations.
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Chapter 22 Solutions
Concepts of Genetics (12th Edition)
Ch. 22 - In order to vaccinate people against diseases by...Ch. 22 - Prob. 2NSTCh. 22 - Prob. 1CSCh. 22 - Prob. 2CSCh. 22 - Prob. 3CSCh. 22 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 22 - Prob. 2PDQCh. 22 - Why are most recombinant human proteins produced...Ch. 22 - One of the major causes of sickness, death, and...Ch. 22 - Sequencing the human genome, the development of...
Ch. 22 - Prob. 6PDQCh. 22 - As genetic testing becomes widespread, medical...Ch. 22 - Prob. 8PDQCh. 22 - Prob. 9PDQCh. 22 - Does genetic analysis by ASO testing allow for...Ch. 22 - Maternal blood tests for three pregnant women...Ch. 22 - What is the main purpose of genome-wide...Ch. 22 - Describe how the team from the J. Craig Venter...Ch. 22 - Prob. 14PDQCh. 22 - Prob. 15PDQCh. 22 - Dominant mutations can be categorized according to...Ch. 22 - In 2013 the actress Angelina Jolie elected to have...Ch. 22 - Prob. 18PDQCh. 22 - Should the FDA regulate direct-to-consumer genetic...Ch. 22 - Prob. 20ESPCh. 22 - Following the tragic shooting of 20 children at a...Ch. 22 - Private companies are offering personal DNA...Ch. 22 - Prob. 23ESPCh. 22 - Prob. 24ESPCh. 22 - Prob. 25ESPCh. 22 - Craig Venter and others have constructed synthetic...
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- Cystic fibrosis (CF) is a genetic disorder affecting a number of organs, including the lung airways, pancreas, and sweat glands. Mutations in both copies of the CFTR gene causes cystic fibrosis. Imagine that you have sweat gland samples from several Cystic Fibrosis patients (A-C) with unknown mutations in CFTR. You also have normal (+) sweat gland sample to use as a positive control. А В С А В С Choose which mutation would explain the RNA and protein results in A, B, & C: 1. Promoter/Regulatory mutation 2. Silent mutation 3. Missense mutation 4. Deletion mutation 5. Splice site mutation 6. Nonsense mutation RNA gel Protein gelarrow_forwardWhat class of mutations do you think would be less likely to lead to CF? Please explain your reasoning.arrow_forwardAn individual carries a disease-causing point mutation. Briefly describe four methods that can be used to identify this mutation.arrow_forward
- An experiment was performed in mice. Wild-type bone marrow is used to reconstitute lethally irradiated Cr2-/- mice (wt®Cr2-/-), or vice versa (Cr2-/-®wt). As controls, Cr2-/- bone marrow is used to reconstitute Cr2-/- recipients (Cr2-/-®Cr2-/-), and wild-type bone marrow used to reconstitute wild-type recipients (wt®wt). These mice are then inoculated with the HSV-rd virus at 106 PFU, once at day 0 and then a second time at day 28, and the anti-HSV IgG responses are measured every 7 days, as shown in figure below. a) From the data shown above, on which cell type is the expression of the complement receptor most important for humoral immunity? b) For each of the cell types expressing the complement receptor encoded by Cr2, what is the explanation for their importance in humoral immunity to HSV inoculation?arrow_forwardRegarding the production of monoclonal antibodies, it is CORRECT to state that: * A) Hybridomas are cells generated from the fusion of myeloma cells and cells from animals challenged with the antigen of interest that have the ability to produce antibodies and limited cell proliferation. B) All hybrid cells generated from the fusion of cells from the challenged animal and cells of the myeloma lineage will have the ability to produce antibodies reactive against the antigen of interest. C) The HAT selection medium contains aminopterin, which is an efficient inhibitor of the thymidine kinase metabolic pathway, thus eliminating myeloma cells that are not fused or fused with other cells of the same kind. D) The HAT selection medium contains hypoxanthine, which is an efficient inhibitor of the nucleotide synthesis salvage pathway, thus eliminating cells from the challenged animal that are not fused or fused with other identical cells. E) Hybridomas will produce antibodies with the…arrow_forwardmin+ = confers resistance to minocycline cep+ = confers resistance to cephalexin van+ = confers resistance to vancomycin The following table shows the results of your experiments. Transformation of the recipient cells was conducted, using the DNA of the donor cells. You next selected for recipient cells that had undergone transformation by plating the transformed cells on media containing minocycline. This enabled you to select for min+ cells. The min+ cells were then replica plated onto media containing cephalexin or vancomycin in order to determine the antibiotic resistance phenotypes with respect to these other two antibiotics Questions a) Of the three potential orders of these genes, which orders are possible and which are impossible based on your knowledge of the relative distance? b) Finally, determine the correct order of the three genes. Please include a DIAGRAM to illustrate how you deduced the correct gene order, as well as an explanation of your reasoning.arrow_forward
- a. Briefly discuss (using three sentences) how the concepts and/or techniques in molecular biology are applied in COVID-19 pandemic, and: b. For each topic (Covid-19 pandemic), give any issues, benefits, or drawbacks of the application (still using three sentences).arrow_forwardA research group is studying a bacterium X that binds to mucosal cells in the lung and invades. Wildtype X has an LD50 value of 10 bacteria when administered to mice by inhalation. Using transposon mutagenesis, the researchers have isolated two mutants of X that they call Xmut1 and Xmut2, both of which have LD50 values of 105 when inhaled by mice. However, in tissue culture cells, Xmut1 can invade the cells just as well as wild-type X, while Xmut2 cannot. Provide a possible explanation for these results.arrow_forwardExplain why mutational resistance in Mycobacterium tuberculosis is of much importance in the treatment of tuberculosis.arrow_forward
- The first mutation is thought to occur in utero in most cases of ALL diagnosed before age 5 years Select one: A.Survival in children between age 2 and 10 years is now about 75% B.It is more frequent in males than females C.Peak age of onset is 2–4 years D.Females have a better prognosis than malesarrow_forwardGive a schematic diagram of how we can Treatment Thalassemia by using gene therapy? Please answer at your own words,please..arrow_forwardWhich statement below is consistent with making a Type I error?arrow_forward
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