Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 22, Problem 20E
Summary Introduction

To explain: The reason why the mice that are deficient in UCP1 become obese when raised at 28ºC but not at 20ºC.

Concept introduction: UCP1 or uncoupling protein, earlier named as thermogenin, is an uncoupling protein that is found in the mitochondria of brown adipose tissue. This uncoupling protein is used to generate heat by non-shivering thermogenesis. The methods to deliver UCP1 to cells by gene transfer therapy or the methods of its upregulation play an important role in the research for the treatment of obesity.

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY