Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 20, Problem 25P
Interpretation Introduction
Interpretation:
The enzyme which is the regulatory enzyme in the oxidative phase of the pentose phosphate pathway is to be identified.
Concept introduction:
The
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Match the description with the correct enzyme.
Descriptions:
a. Uses alpha-keto carboxylic acid as a substrate
b. Directly transfers cytosolic reducing equivalents into the electron transport chain
c. Its activity depends on magnesium ions
Options (enzymes):
A.
Mitochondrial glycerol 3-phosphate dehydrogenase
B.
Succinate dehydrogenase
C.
Cytosolic glycerol 3-phosphate dehydrogenase
D.
Cytochrome oxidase
E.
Rubisco
F.
α-ketoglutarate dehydrogenase complex
Match the enzyme to the reaction catalysed. Not all the enzymes have to be selected, and an enzyme may be used more than once.
v Synthesizes phosphatidic acid
A. Glycerol-3-phosphate dehydrogenase
v Synthesizes triacylglycerol
B. Glycerol kinase
v Synthesizes acetoacetyl-CoA
C. Acyl-CoA cholesterol acyl transferase
v Synthesizes mevalonate
D. Lipin
v Synthesize 1,2 diacylglycerol
E. Acyl transferase
v Converts glycerol into glycerol-3-phosphate
F. HMG-CoA reductase
v Converts dihydroxyacetone phosphate into glycerol-3-phosphate
G. Thiolase
v Synthesize cholesterol-ester
For the pyruvate dehydrogenase complex, please identify the oxidation states of every atom and prove whether the reaction is oxidized or not
Pyruvate --> Hydroxyethyl TPP
B. Hydroexythl TPP --> Acetyl Lipoylysine
C. Acetyl Lipoylysine --> Acetyl-CoA
Chapter 20 Solutions
Biochemistry
Ch. 20 - Prob. 1PCh. 20 - Prob. 2PCh. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - Prob. 5PCh. 20 - Prob. 6PCh. 20 - Prob. 7PCh. 20 - Prob. 8PCh. 20 - Prob. 9PCh. 20 - Prob. 10P
Ch. 20 - Prob. 11PCh. 20 - Prob. 12PCh. 20 - Prob. 13PCh. 20 - Prob. 14PCh. 20 - Prob. 15PCh. 20 - Prob. 16PCh. 20 - Prob. 17PCh. 20 - Prob. 18PCh. 20 - Prob. 19PCh. 20 - Prob. 20PCh. 20 - Prob. 21PCh. 20 - Prob. 22PCh. 20 - Prob. 23PCh. 20 - Prob. 24PCh. 20 - Prob. 25PCh. 20 - Prob. 26PCh. 20 - Prob. 27PCh. 20 - Prob. 28PCh. 20 - Prob. 29PCh. 20 - Prob. 30PCh. 20 - Prob. 31PCh. 20 - Prob. 32PCh. 20 - Prob. 33PCh. 20 - Prob. 34PCh. 20 - Prob. 35PCh. 20 - Prob. 36PCh. 20 - Prob. 37PCh. 20 - Prob. 38PCh. 20 - Prob. 39PCh. 20 - Prob. 40PCh. 20 - Prob. 41PCh. 20 - Prob. 42PCh. 20 - Prob. 43PCh. 20 - Prob. 44PCh. 20 - Prob. 45PCh. 20 - Prob. 46PCh. 20 - Prob. 47PCh. 20 - Prob. 48P
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- The rate limiting and committed step of the pentose phosphate pathway is catalyzed by which of the following enzymes? A. Glucose-6-phosphate dehydrogenase B. Hexokinase C. 6-Phosphogluconate dehydrogenase D. Transketolasearrow_forwarda. In the TCA cycle, which of the following combines with acetyl CoA to form a 6-carbon compound? i. oxaloacetate ii. thiamine iii. glucose iv. pyruvate b. The last step in glycolysis is the transfer of phosphoryl group from phosphoenolpyruvate to ADP catalyzed by pyruvate kinase. i. True ii. Falsearrow_forwardYou have a crude lysate sample (CL) containing a mixture of six proteins (1, 2, 3, 4, 5, ẞ- galactosidase), and your goal is to obtain purified ẞ-gal. Some characteristics of these proteins are shown in the table below. Protein Alcohol dehydrogenase Carbonic anhydrase Insulin B chain Phosphorylase B Glutamic dehydrogenase B-galactosidase 45% Concentration of ammonium sulfate (AS) required for precipitation Molecular Weight (kDa) Isoelectric point (pl) 38 3.7 80% 65% 20% 30% 45% 28 4.8 4 5.3 98 6.8 49 9.5 115 5.3 You begin your purification by performing an ammonium sulfate (AS) precipitation. You add the appropriate concentration of AS to your CL sample, incubate overnight at 4°C, then centrifuge to generate a supernatant (AS-S) and pellet (AS-P). What concentration of AS will you use to precipitate Glutamic dehydrogenase? © 20% O 30% 45% 65% 80%arrow_forward
- A. Identify different types of organic reaction mechanims in the followingmetabolic pathways.1. Catabolism of triacylglycerols- beta-oxidation pathway2. Biosynthesis of fatty acids from Acetyl CoA3. Glycolysis (from glucose to two molecules of pyruvate)4. Conversion of Pyruvate to Acetyl CoA5.Citric acid cycle6. Gluconeogensis pathway (pyruvate to glucose) B. Identify at most 5 organic reactions for each metabolic pathway.arrow_forwardMatch the item to each step in the Krebs Cycle. Write your answers on the Google Form. isocitrate f. Oxaloacetate a. b. succinate g. Sulfur NAD* h. a-ketoglutarate fumarate C. d. malate i. succinyl-CoA j. ATP e. What molecule combines with acetyl-CoA and then releases CoA? 66. What molecule is oxidized by NAD+ to become a 5- carbon compound? 67. What molecule is oxidized by NAD+ to become a 4- carbon compound? 68. 69. What 4-carbon molecule is formed when combined with COA? 70. What molecule is produced when CoA is released? 71. What molecule is formed when GTP is oxidized to form GDP? 72. What atom is the bridge that connects to CoA? 73. What molecule is formed when FAD is reduced? 74. What molecule is formed with the addition of H,O? 75. Which molecule must be reduced so that oxaloacetate is formed? Match the product to the process. Write your answer on the Google Form. GTP f. CO, а. b. phosphofructinase NADH* + CO, g. Citrate formed. c. h. ATP d. Co-A i. Isocitrate HO j- Pyruvate e.…arrow_forwardMatch the description with the correct enzyme : A. Glucose 6-phosphate dehydrogenase Serves a as a direct link between citric acid cycle and electron transport chain B. Succinate dehydrogenase v Uses alpha-keto carboxylic acid as a substrate C. Alcohol dehydrogenase Does not contribute electron carriers to oxidative phosphorylation D. NADH dehydrogenase E. Isocitrate dehydrogenase F. Pyruvate dehydrogenase complexarrow_forward
- Five coenzymes are required by a-ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts a-ketoglutarate to succinyl-CoA.a. Identify the coenzymes.b. Propose a mechanism for the reaction. A-ketoglutarate dehydrogenase A-ketoglutarate succinyl-CoAOO OO O−O O− −O SCoA + CO2arrow_forwardA. What would happen in the Krebs cycle with the loss of activity of phosphoglycerate kinase? What would happen in glycolysis? 10. What happens to glycolysis with the addition of high amounts of citrate? What happens to ETS? 11. What happens in the Krebs cycle with a block in fumerase? 12.If an amino acid enters the Krebs cycle at the acetyl CoA entry point, how much more ATP is being made than if it enters at a keto-glutarate?arrow_forwardIn the context of fatty acid oxidation to acetyl CoA, indicate whether each of the following substances is involved in (1) fatty acid activation, (2) fatty acid trans-port, or (3) b-oxidation pathway. More than one choice may be correct in a given situation. a. AMp b. FAD c. Acyl CoA d. H2Oarrow_forward
- Indicate what will happen ( increase, decrease or no effect) tothe activity of the enzyme or rate of the metabolic pathway in the given conditions a. release of glucagon in the blood to the activity of carnitine acyl transferase 1 b. high malonyl CoA to the activity of carnitine acyl transferase I C. Epinephrine to the activity og glycogen synthase d. high citrate to the activity of acetyl CoA carboxylase e. high acetyl CoA to ketogenesisarrow_forwardWhich of the following catalyzes a step that does NOT produce CO2? Group of answer choices alpha-ketoglutarate dehydrogenase complex malate dehydrogenase pyruvate dehydrogenase complex isocitrate dehydrogenase Citrate synthase is regulated by... Group of answer choices Concentrations of substrate and products Fructose-2,6-Bisphosphate Covalent modification Allosteric regulation by the levels of NADDHarrow_forwardConsider the docosanoic acid, C21H43CO2H a. Label the a and B carbons b. Draw the acyl CoA derived from this fatty acid c. How many acetyl CoA molecules are formed by complete B-oxidation? d. How many cycles of B-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid?arrow_forward
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