Human Physiology: From Cells to Systems (MindTap Course List)
Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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Chapter 2, Problem 3SQE
Summary Introduction

To calculate:

The number of calories produced per day in the form of ATP by a resting individual.

Introduction:

ATP is also known as Adenosine triphosphate. It is a molecule which stores energy within cells and is the chief energy currency of the cell. It is the final product of the processes of photophosphorylation, cellular respiration, and fermentation.

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Walking consumes approximately 100 kcal/mi. In the hydrolysis of ATP (ATP → ADP + Pi), the reaction that drives muscle contraction, ΔG°′ is −7.3 kcal/mol (−30.5 kJ/mol). Calculate how many grams of ATP must be produced to walk a mile. ATP synthesis is coupled to the oxidation of glucose (ΔG°′ = −686 kcal/mol). How many grams of glucose are actually metabolized to produce this amount of ATP? (Assume that only glucose oxidation is used to generate ATP and that 40% of the energy generated from this process is used to phosphorylate ADP. The gram molecular weight of glucose is 180 g and that of ATP is 507 g.)
If the DGo for ATP hydrolysis into ADP + inorganic phosphate is -7.3 kcal/mole, and the DGo for sucrose synthesis from glucose + fructose is +5.5 kcal/mole, calculate standard free energy change for the combined reaction of ATP + glucose + fructose g ADP + sucrose + inorganic phosphate. DGo = -12.8 kcal/mole DGo = -1.8 kcal/mole DGo = 0 kcal/mole DGo = +1.8 kcal/mole DGo = +12.8 kcal/mole
B) The actual concentrations of ATP, ADP and Pi differ by tissue/cell type (see table). Tissue/Cell Type ATP (mM) ADP (mM) Pi (mM) Liver 3.5 1.8 5.0 8.0 2.7 Skeletal Muscle 8.0 0.9 Brain 2.6 0.7 Calculate AG' for ATP hydrolysis in liver. (NOTE: assume 25°C and omit the concentration of water in your calculations).

Chapter 2 Solutions

Human Physiology: From Cells to Systems (MindTap Course List)

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