Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 19, Problem 2CS
CASE STUDY| Cancer-killing bacteria
Ralph, a 57-year-old man, was diagnosed with colon cancer. His oncologist discussed the use of radiation and chemotherapy as treatments for this cancer and explained that each of these therapies kills actively dividing normal and cancer cells, causing debilitating side effects. Ralph decided to carefully review his options and went for a second opinion to a cancer clinic at a major teaching hospital. There he learned that researchers in a synthetic biology program were testing the use of genetically modified E. coli that selectively invade and kill cancer cells, with no effects on normal cells. Ralph decided to participate in this trial, and at an appointment to learn about the details, he was informed that he would be part of a Phase III trial, comparing the effectsof the modified bacterial cells against conventional chemotherapy. As part of the trial, he would be randomly assigned to receive one or the other treatment. He was disappointed to learn this, because he assumed that he would receive the bacterial therapy.
Should he reconsider and try radiation and chemotherapy instead?
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CASE STUDY Cancer-killing bacteria
Ralph, a 57-year-old man, was diagnosed with colon cancer.His oncologist discussed the use of radiation andchemotherapy as treatments, both of which can causedebilitating side effects. Ralph decided to explore other optionsand went to a cancer clinic. He learned that researchers in asynthetic biology program were testing the use of geneticallymodified bacterial cells designed to selectively invade specifictumors and kill cancer cells, with no effects on normal cells.Ralph decided to participate and was informed that he wouldbe part of a phase III trial, comparing the effects of the modifiedbacterial cell treatment against conventional chemotherapy.However, as part of the trial, he would be randomly assigned toreceive one or the other treatment. He was disappointed to learnthis, because he assumed that he would receive the bacterialtherapy.Question: Informed consent is legally and ethically required beforesomeone participates in a clinical trial.…
Why is it important to model cancer through the generation of induced pluripotent stem cells ?
Explain in detail the main findings. Please sort as a list.
Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her MD/PhD in cancer therapeutics to treat late-stage pancreatic cancer using a mouse model. Her post-doc will be devoted to targeted mutagenesis of replicative enzymes to halt cell division in cancerous cells. She reviews mitosis and meiosis before reporting for her first day of work.
1) Cancer is essentially unregulated gene growth. Cancer cells sometimes have LOF mutations that affect the production of checkpoint proteins so nothing prevents the cells from continually moving forward and reproducing. If a LOF halted the cell cycle but DNA was still replicated, what check point was affected?
a) The G1 checkpoint.
b) The G2 checkpoint.
c) The G0 checkpoint.
d) The Metaphase checkpoint.
Chapter 19 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 19 - CASE STUDY| Cancer-killing bacteria Ralph, a...Ch. 19 - CASE STUDY| Cancer-killing bacteria Ralph, a...Ch. 19 - CASE STUDY |Cancer-killing bacteria Ralph, a...Ch. 19 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 19 - Prob. 2PDQCh. 19 - Why are most recombinant human proteins produced...Ch. 19 - Prob. 4PDQCh. 19 - One of the major causes of sickness, death, and...Ch. 19 - Prob. 6PDQCh. 19 - Sequencing the human genome and the development of...
Ch. 19 - Prob. 8PDQCh. 19 - As genetic testing becomes widespread, medical...Ch. 19 - What limits the use of differences in restriction...Ch. 19 - Might it make sense someday to sequence every...Ch. 19 - What is the main purpose of genome-wide...Ch. 19 - Prob. 13PDQCh. 19 - Prob. 14PDQCh. 19 -
15. In 2013 the actress Angelina Jolie elected to...Ch. 19 - Prob. 16PDQCh. 19 - Should the FDA regulate direct-to-consumer genetic...Ch. 19 - Prob. 18PDQCh. 19 - Prob. 19PDQCh. 19 - Private companies are now offering personal DNA...Ch. 19 - Yeager, M., et al.(Nature Genetics 39: 645–649,...Ch. 19 - In March 2010 Judge R. Sweet ruled to invalidate...
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