Hi, can you elaborate about these two concepts: 1) Can telomere inhibition be good cancer treatment?  2) Can cancer steam cells hypothesis be a good / bad approach?

Imagine that you are a scientist who wants to better understand the genetic mechanisms underlying cancer. Match each of the experiments with the model oryanism that would best help build foundational knowledge for understanding cancer in humans. Mus musculus Saccharomyces cerevisiae Arabidopsis thaliana Answer Bank determining how radiation affects growth in the presonce of a mutated IRCAI oritolog anensing viability and analyring tumor development in transgenic lines containing BRCA/ and BRCA2 mutations analyring how analogous cancer-oontrolling genes and ultraviolet B (UV-B) adaptive loci are selated to stress esponses stimulating and inhibiting cell division cycle penes to determine the effect on cell proliferation

19: What are 3 phenotypes of GA, or BR, or ABA, or CK over-producing mutants.   20: Think about a hormone receptor, specifically the structure of the receptor. Describe ONE why a mutation would cause insensitivity to the hormone, AND ONE way it could cause hypersensitivity to the hormone. Explain your answer to each.   22: Not all cells in tissues are the same. They differentiate from stem cells. Describe how ONE cell type acquires cell identity. (Pick any cell in the plant)

1. Cancer genetics Breast cancers can be divided into several classes. One type of breast cancer, classified as HER2 positive ("HER2+"), represents 15-20% of breast cancers. Most HER2+ cancers arise due to amplification of the HER2 gene (without any mutation of the HER2 protein coding region). HER2 amplification is also associated with several other types of cancer (e.g. stomach cancer). Would the HER2 gene be considered a proto-oncogene or a tumor suppressor gene? Justify your answer based on the function of the HER2 protein (look it up). b. How does amplification of HER2 promote cancer? c. Some HER2+ cancers have become resistant to the antibody drug. These cells were found to have mutations of the PTEN gene (look for information about the PTEN gene). Are these likely to be recessive loss of function mutations or dominant gain of function mutations of PTEN? Justify your answer, relating PTEN mutations to drug resistance.

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