Concept explainers
Interpretation:
The way to distinguish between a competitive inhibitor and an uncompetitive inhibitor experimentally should be given.
Concept Introduction:
Enzyme inhibitors: The substance which slows or stops the action of an enzyme is called enzyme inhibitors.
It can be used as drugs and an example is AZT which is used to treat HIV.
The competition of an enzyme can be reversible or irreversible and in reversible inhibition, the inhibitor can leave and in irreversible inhibition, the inhibitor remains permanently bound.
Reversible Competitive inhibition: It is a type of inhibition occurs when the inhibitor resembles very much to the substrate and thus prevents the substrate binding.
Reversible uncompetitive inhibition: It is a type of enzyme regulation in which an inhibitor binds reversibly to the enzyme-substrate complex and thereby blocking the binding of the second substrate to the binding site.
Irreversible competitive inhibition: It is a type of inhibition in which an inhibitor forms covalent bonds to the active site and thereby permanently blocking it.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Define the following terms: a. competitive inhibitor b. uncompetitive inhibitor c. noncompetitive inhibitor d. reversible inhibitor e. irreversible inhibitorarrow_forwardWhy can we say that having a pure non- competitive inhibitor present is similar to just having less enzyme present?arrow_forwardPlease name the differences between competitive and noncompetitive inhibition.arrow_forward
- Is the inhibitor competitive uncompetitive or non competitive? Why?arrow_forwardWhat is the difference between competitive and noncompetitive inhibitors?arrow_forwardWhy might an enzyme’s substrate, transition state, and product all serve as starting points for the design of a competitive inhibitor?arrow_forward
- What is the difference between competitive and non-competitive inhibition? How can each be reversed?arrow_forwardWhy are uncompetitive and mixed inhibitors generally considered to be more eff ective in vivo than competitive inhibitors?arrow_forwardWhat are the possible effects and changes on the Michaelis-Menten equation that can result from competitive, noncompetitive, mixed noncompetitive and uncompetitive inhibitors?arrow_forward
- Name one advantage of a noncompetitive inhibitor as a potential drug compared with a competitive inhibitorarrow_forwardDetermine whether the following statements describe a reversible competitive inhibitor, a reversible noncompetitive inhibitor, or an irreversible inhibitor. Both the inhibitor and the substrate cannot bind to the enzyme at the same time. The structure of the inhibitor is similar to that of the substrate. The addition of more substrate can reverse the inhibitor effect It forms a covalent bond with the active site.arrow_forwardExplain the difference between an irreversible inhibitor and areversible, competitive inhibitor.arrow_forward
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