Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 19, Problem 18RQ
Summary Introduction

To determine: The effect of constriction of afferent arteriole on glomerular filtration rate.

Introduction: The nephron is the smallest functional units of the kidneys. They are made up of different parts like glomerulus, Bowman’s capsule, proximal convoluted duct, distal convoluted duct, collecting duct, and Loop of Henle.

Summary Introduction

To determine: The effect of constriction of efferent arteriole on glomerular filtration rate.

Introduction: The different parts of nephron perform different functions, which include ultrafiltration and absorption of water and ions from the urine and excrete out the wastes and toxins from the body through urine.

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The distal nephron is able to fine-tune sodium and water balance because it can regulate reabsorption of sodium and water independently of each other. This is unlike the proximal nephron, where an increase in sodium reabsorption will lead to an increase in water reabsorption due to the creation of an osmotic gradient and free permeability to both sodium and water. How does vasopressin affect water reabsorption in the distal nephron in response to a negative water balance? Increased circulating vasopressin increases expression of aquaporin on the luminal membrane. O Increased circulating vasopressin decreases expression of aquaporin on the luminal membrane. Decreased circulating vasopressin increases expression of aquaporin on the luminal membrane. Decreased circulating vasopressin decreases expression of aquaporin on the luminal membrane.
Aldosterone affects sodium balance by impacting sodium reabsorption in the distal nephron. If MAP and/or GFR falls, how will this system function? Increased levels of aldosterone add epithelial sodium channels (ENaCs) to the luminal membrane of the collecting duct. Increased levels of aldosterone remove epithelial sodium channels (ENaCs) from the luminal membrane of the collecting duct. Decreased levels of aldosterone allow increased expression of epithelial sodium channels (ENaCs) in the collecting duct. O Decreased levels of aldosterone decrease expression of epithelial sodium channels (ENaCs) in the collecting duct.
Explain why the filtrate becomes hypotonic as it flows through the ascending limb of the nephron loop. Also explain why the filtrate at the bend of the nephron loop (and the interstitial fluid of the deep portions of the medulla) is hypertonic.

Chapter 19 Solutions

Human Physiology: An Integrated Approach (8th Edition)

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