Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 17, Problem 7PDQ
Provide a brief description of two different types of histone modification and how they impact transcription.
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Discuss how the expression of a protein can be regulated post transcription in eukaryotic cells through, using the following key terms:
Degradation of mRNA (two ways)
Blocking translation
Degradation of the protein
Define regulatory mutation. Describe how an insertion, deletion, or substituion of a base pair in a promoter might affect the transcription driven by that promoter.
Determine whether the following will increase or decrease gene expression:
mRNA degradation
mRNA capping
Binding of a transcriptional activator
Ubiquitination of a protein and targeting to the proteasome
Chapter 17 Solutions
Concepts of Genetics (12th Edition)
Ch. 17 - Cancer cells often have abnormal patterns of...Ch. 17 - The hormone estrogen converts the estrogen...Ch. 17 - Each year in the United States, there are over...Ch. 17 - Prob. 2CSCh. 17 - Each year in the United States, there are over...Ch. 17 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 17 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 17 - What features of eukaryotes provide additional...Ch. 17 - Provide a definition of chromatin remodeling, and...Ch. 17 - Describe the organization of the interphase...
Ch. 17 - A number of experiments have demonstrated that...Ch. 17 - Provide a brief description of two different types...Ch. 17 - Present an overview of the manner in which...Ch. 17 - Prob. 9PDQCh. 17 - Explain how the addition of acetyl groups to...Ch. 17 - Distinguish between the cis-acting regulatory...Ch. 17 - Prob. 12PDQCh. 17 - Describe the manner in which activators and...Ch. 17 - Compare the control of gene regulation in...Ch. 17 - Many promoter regions contain CAAT boxes...Ch. 17 - Prob. 16PDQCh. 17 - Prob. 17PDQCh. 17 - Many transcriptional activators are proteins with...Ch. 17 - Prob. 19PDQCh. 17 - DNA supercoiling, which occurs when coiling...Ch. 17 - Prob. 21ESPCh. 17 - Prob. 22ESPCh. 17 - Because the degree of DNA methylation appears to...Ch. 17 - A particular type of anemia in humans, called...Ch. 17 - Regulation of the lac operon in E. coli (see...Ch. 17 - DNA methylation is commonly associated with a...Ch. 17 - During an examination of the genomic sequences...Ch. 17 - Prob. 28ESPCh. 17 - Although a single activator may bind many...Ch. 17 - Hereditary spherocytosis (HS) is a disorder...Ch. 17 - Transcription factors play key roles in the...
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- Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.arrow_forwardWhat is meant by the term transcription factor modulation? List three general ways this can occur.arrow_forwardExplain how histone modifications affect transcription.arrow_forward
- Describe how transcription in prokaryotic cells can be altered by external stimulation such as excess lactose in the environment.arrow_forwardDefine both transcription and translation. In addition, describe the role(s) of each of the following in the processes of gene expression and protein synthesis: DNA, mRNA, tRNA, rRNA, ribosome(s), RNA polymerase, codon, anticodon, amino acid(s) and polypeptide(s). Be detailed in your answer.arrow_forwardDescribe how mature messenger ribonucleic acids (MRNAS) are post-transcriptionally processed in the nucleus before they are transported to the cytoplasm of a eukaryotic cell.arrow_forward
- Describe what happens to the chemical bonding interactions when transcriptional termination occurs. Be specific about the type of chemical bonding.arrow_forwardDefine the basic requirements for histone modifications ?arrow_forwardDescribe the post-transcriptional modifications that occur in mRNA and tRNA.arrow_forward
- Explain the fundamental differences between negative control and positive control of transcription in prokaryotes. Cite two examples of each control mechanism.arrow_forwardExplain why histone eviction or displacement is needed for the elongation phase of transcription to occur.arrow_forwardExplain three types of post-transcriptional modifications to RNA.arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY