Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 15.5, Problem 3CC
WHAT IF? Ø Mitochondrial genes are critical to the energy
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In terms of energy transduction (a) in what way are mitochondrial complexes I,
II, and IV similar? And (b) in what way are they different?
During the FADH2 electron transport chain,
the protons are pumped from the mitochondrial matrix to the intermembrane space through complexes CoQ/III, and IV
the protons are pumped from the mitochondrial matrix to the intermembrane space through complexes I, CoQ/III, and IV
the protons are pumped from the mitochondrial matrix to the intermembrane space through complexes I, CoQ/II, and IV
the protons are pumped from the mitochondrial matrix to the outer mitochondrial membrane through complexes I, III, and IV
1. Name and draw diagrammatically the series of mitochondrial electron transfer catalysts, starting with the oxidation of NADH and succinate and
ending with the reduction of O2.
2. Indicate the sites and stoichiometry (per 2e) at which protons are translocated from the matrix to the intermembrane space.
3. Indicate which complexes are inhibited by: amytal, antimycin A, azide (N3 ), cyanide (CN), carbon monoxide (CO), and rotenone.
4. Describe the effects of (1) oligomycin and (2) uncouplers of oxidative phosphorylation, e.g., dinitrophenol (DNP), carbonyl cyanide-p-
trifluoromethoxyphenylhydrazone (FCCP), on respiration and ATP synthesis when added to a suspension of mitochondria with excess malate, ADP,
and inorganic phosphate (Pi).
Chapter 15 Solutions
Campbell Biology
Ch. 15.1 - MAKE CONNECTIONS Review the description of...Ch. 15.1 - WHAT IF? Propose a possible reason that the first...Ch. 15.1 - Which one of Mendel's laws describes the...Ch. 15.2 - A white-eyed female Drosophila is mated with a...Ch. 15.2 - Neither Tim nor Rhoda has Duchenne muscular...Ch. 15.2 - MAKE CONNECTIONS Consider what you learned about...Ch. 15.3 - When two genes are located on the same chromosome,...Ch. 15.3 - VISUAL SKILLS For each type of offspring of the...Ch. 15.3 - Prob. 3CCCh. 15.4 - Prob. 1CC
Ch. 15.4 - Prob. 2CCCh. 15.4 - Prob. 3CCCh. 15.5 - Gene dosagethe number of copies of a gene that are...Ch. 15.5 - Reciprocal crosses between two primrose varieties,...Ch. 15.5 - WHAT IF? Mitochondrial genes are critical to the...Ch. 15 - What characteristic of the sex chromosomes allowed...Ch. 15 - Why are males affected by X-Iinked disorders much...Ch. 15 - Why are specific alleles of two distant genes more...Ch. 15 - Prob. 15.4CRCh. 15 - Explain how genomic imprinting and inheritance of...Ch. 15 - A man with hemophilia (a recessive, sex-linked...Ch. 15 - Pseudohypertrophic muscular dystrophy is an...Ch. 15 - Prob. 3TYUCh. 15 - A planet is inhabited by creatures that reproduce...Ch. 15 - Prob. 5TYUCh. 15 - A wild-type fruit fly (heterozygous for gray body...Ch. 15 - Assume that genes, A and B are on the same...Ch. 15 - Two genes of a flower, one Controlling blue (B)...Ch. 15 - Prob. 9TYUCh. 15 - Banana plants, which are triploid, are seedless...Ch. 15 - Prob. 11TYUCh. 15 - SCIENTIFIC INQUIRY DRAW IT Assume you are mapping...Ch. 15 - WRITE ABOUT A THEME: INFORMATION The continuity of...Ch. 15 - SYNTHESIZE YOUR KNOWLEDGE Butter flies have an X-Y...
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- 1a. Name and draw diagrammatically the series of mitochondrial electron transfer catalysts, starting with the oxidation of NADH and succinate and ending with the reduction of O2. Indicate the sites and stoichiometry (per 2e) at which protons are translocated from the matrix to the intermembrane space. c. Indicate which complexes are inhibited by: amytal, antimycin A, azide (N3), cyanide (CN), carbon monoxide (CO), and rotenone. d. Describe the effects of (1) oligomycin and (2) uncouplers of oxidative phosphorylation, e.g., dinitrophenol (DNP), carbonyl cyanide-p- trifluoromethoxyphenylhydrazone (FCCP), on respiration and ATP synthesis when added to a suspension of mitochondria with excess malate, ADP, and inorganic phosphate (Pi). b. Iarrow_forward25. The following graph illustrates the consumption of oxygen in a mitochondrial preparation. Draw, on the graph, what would happen to oxygen concentration in the mitochondria under each of the following conditions (in other words, your final graph should have 4 different lines on it, clearly labeled a, b, c, and d) A .3 dte: 0cT ON 01E.0 .2t .1 1 2 3 Time, min (a) NADH (but nothing else) is added at the time marked A (b) NADH plus ADP is added at the time marked A. (c) NADH plus ADP plus a drug that prevents ATP synthase from binding to ADP at the time marked A. (d) NADH plus ADP plus a drug that prevents ATP synthase from binding ADP at the time marked A, followed by a drug that makes the inner membrane space more basic 1 minute later. [02], mMarrow_forwardMitochondrial outer membrane permeabilization (MOMP) includes: Question 10 options: a) mitochondrial outer membranes are disrupted. b) caspases activation in either intrinsic or extrinsic pathway. c) cytochrome c release. d) All of the above. e) Only (a) and (c)arrow_forward
- WHAT IF? Mitochondrial genes are critical to the energymetabolism of cells, but mitochondrial disorders caused bymutations in these genes are generally not lethal. Why not?arrow_forwardPFor each of the following experiments, tell me whether you would expect the rate of O₂ consumption and ATP synthesis to increase, decrease or remain the same (respectively). Assume there is plenty of O₂ around. (a) Succinate is suddenly added to mitochondria that have no other oxidizable substrates (Assume that there are ADP and Pi in mitochondria). (b) ADP is not allowed to pass into the mitochondrial matrix. (c) 2,4 Dinitrophenol (an uncoupler) is added.arrow_forward10. ATP synthase is a key enzyme of mitochondrial energy conversion. Mitochondrial ATP synthase deficiency is due to a mutation in a gene important for the formation of a subunit in the ATP synthase complex, seen in the illustration below. Scientists could use cells with this gene mutation to investigate which of the following questions? (LS1-7) * Inner mitochondrial membrane PYRUVATE GLYCOLYSIS ODATION ACO CYCLE OXIDATIVE PHOSPHORYL- ATION ATP synthase Protein complex of electron Intermembrane- space carriers III Inner mitochondrial membrane FADH, FAD 2 H* + ½02 H,0 NAD NADH (carrying electrons from food) ADP + O АТР Mitochondrial matrix Oxidative phosphorylation What effect does the mutation have on the movement of electrons between the electron carriers of the electron transport chain? What effect does the mutation have on the amount of ATP synthesized during cellular respiration? What effect does the mutation have on the number of protons pumped into the intermembrane space of the…arrow_forward
- 1. a) Describe the Q cycle in detail providing the names of electron acceptors and donors. b) How is ATP synthesized by the FOF1 Complex in the mitochondrial membrane?arrow_forwarda) Make a theoretical calculation of how many ATP molecules can be formed from the breakdown of a molecule of Acetyl- CoA into carbon dioxide and water. The prerequisite is that the entire proton gradient across the mitochondrial inner membrane can be used for ATP production and that the ATP synthase has 6 c-subunits.arrow_forwardExplain the functions of mitochondrial matrix processing peptidase (MP) and chloroplast stromal processing peptidase (SPP).arrow_forward
- Mitochondria are critical for normal metabolism. From which parent did each human being’s original mitochondria come from at conception? In Luft’s syndrome the mitochondria are not producing sufficient amounts of ATP. What series of reactions could be most responsible for the deficiency? What are some other conditions that are thought to involve mitochondrial malfunction? What's your opinion on the 3-parent babies technique approved in the UK?arrow_forwardA central tenet in mitochondrial bioenergetics is that exergonic electron transfer drives the creation of an electrical potential () across the inner mitochondrial membrane (IMM). This is entirely true. Another tenet of mitochondrial bioenergetics, that you will read everywhere, is that this electrical potential is created by three proton pumps, Complexes I, III and IV. This is less true. A proton pump is this: It’s a protein that binds a proton from one side of a membrane, translocates that very proton across the membrane, through the protein, and ejects it into solution on the other side of the membrane. Complex I is a proton pump, but we did not discuss complex I. Complex III is NOT a proton pump, yet it creates electrical potential across the IMM. It is an electron/proton charge separation device. Complex IV is both types of these devices. Fifty percent of the electrical potential that complex IV creates is as a proton pump. But, 50% of the electrical potential that complex IV…arrow_forwardIn oxidative phosphorylation (mark all that are true)... Choice 1 of 7:Succinate contributes 2e- to Complex II and 2H+ to the mitochondrial proton gradient. Choice 2 of 7:NADH in the matrix passes 2 e- to coenzyme Q via Complex I. Choice 3 of 7:Complexes I, II, III, and IV each contribute to the matrix proton gradient. Choice 4 of 7:O2 stabilizes the catalytically active conformation of Complex V. Choice 5 of 7:Reversible protonation of c subunits leads to rotation of the Complex V gamma subunit. Choice 6 of 7:Each β subunit can bind ATP tightly under the right conditions. Choice 7 of 7:For every 3 protons that pass across the inner mitochondrial membrane, 1 ATP is produced. Below are screenshots of the answer from two different sources (for your consideration)arrow_forward
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