Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 15, Problem 2TYU

Pseudohypertrophic muscular dystrophy is an inherited disorder that causes gradual deterioration of the muscles. It is seen almost exclusively in boys born to apparently unaffected parents and usually results in death in the early teens. Is this disorder caused by a dominant or a recessive allele? Is its inheritance sex-linked or autosomal? How do you know? Explain why this disorder is almost never seen in girls.

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Pseudohypertrophic muscular dystrophy is an inheriteddisorder that causes gradual deterioration of the muscles. It isseen almost exclusively in boys born to apparently unaffectedparents and usually results in death in the early teens. Isthis disorder caused by a dominant or a recessive allele?Is its inheritance sex-linked or autosomal? How do youknow? Explain why this disorder is almost never seen in girls.
Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia.     What are the genotypes of Jane and Paul? If they plan to have four children, what is the probability that:  all their children will be normal?  _________________________________   they will have a son with Huntington’s disease? _________________________   they will have a daughter inflicted with both conditions?________________
Two normal parents have a child with cyatic fibrosis. Would this be an autosomal dominant or autosomal recessive disorder? What is the chance that their next child will have cystic fibrosis?

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