Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 15.3, Problem 2R
Summary Introduction
To review:
The process by which a gene mutation is mapped and detected before knowing its protein product.
Introduction:
The process in which sudden heritable changes (either in structure or in content) in genotype occurs, is called a mutation. These mutations, most of the time, lead to many diseases. To identify the disease, deoxyribonucleic acid (DNA) markers are used for linkage analysis.
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Life: The Science of Biology
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- While a stem cell transplant from an unaffected donor is currently the only cure for DBA, genome-editing technologies may one day enable the correction of a mutation in a patient’s own bone marrow stem cells. However, what specific information would be needed, beyond a symptom-based diagnosis of DBA, in order to accomplish this?arrow_forwardGene mutations can be classified in two major ways:(1) hereditary or germline mutations that are inherited from a parent and are present throughout a person’s life in virtually every cell in the body.(2) acquired or somatic mutations that occur at some time during a person’s life and are present only in certain cells, not in every cell in the body.If there is no family history of a particular disease but a child has the disease then it may have arisen due to a(n) ________ mutation early during development. A) acquired B) inherited C) silent D) transitionarrow_forwardWhat is gene knockout ?arrow_forward
- what is another type of disease caused by a duplication mutation? How does it present itself?arrow_forwardThe nurse is explaining the general goal of gene therapy to a patient. With gene therapy, the general goal is to transfer exogenous genes to a patient for which result? a )To change the patient’s own genetic functioning to treat a given disease b )To improve drug metabolism c )To prevent genetic disorders in the patient’s future children d )To stimulate the growth of stem cellsarrow_forwardWhich of the following is an enabling characteristic for cancer that can increase the likelihood of both passenger and driver mutations? a) Increased angiogenesis O b) Tumor-promoting inflammation O c) Avoiding immune destruction O d) Genome instability acerarrow_forward
- What is the key component(s) of usher syndrome.A) The Effect of mutation and Hot-spots of mutation?B) What happens when things go wrong?arrow_forwardDefine gene knockout.arrow_forwardA neutral mutation is, by definition, a mutation that does not result in the change of the encoded amino acid sequence of a gene. 1)True 2)Falsearrow_forward
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