The description of mutation, which would affect nucleotides, outside the coding region of a gene (beta-globin gene). Introduction: Mutations are permanent and heritable changes of the genome. They can result in diseases by altering the protein sequences. An altered protein sequence either folds incorrectly or does not fold at all. This consequence can render a protein dysfunctional and can cause diseases in the organism.

Question

The protein encoded by the cystic fibrosis gene is 1480amino acids long, yet the gene spans 250 kb. How is thisdifference possible?

Answer 1

Question

Chapter 15, Problem 2Q

Summary Introduction

To review:

The description of mutation, which would affect nucleotides, outside the coding region of a gene (beta-globin gene).

Introduction:

Mutations are permanent and heritable changes of the genome. They can result in diseases by altering the protein sequences. An altered protein sequence either folds incorrectly or does not fold at all. This consequence can render a protein dysfunctional and can cause diseases in the organism.

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The protein encoded by the cystic fibrosis gene is 1480amino acids long, yet the gene spans 250 kb. How is thisdifference possible?

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