Microbiology: An Introduction (13th Edition)
13th Edition
ISBN: 9780134605180
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case, Derek Weber, Warner Bair
Publisher: PEARSON
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Chapter 15, Problem 10R
Summary Introduction
To review:
The OPA1 protein involved in the process of oxidative phosphorylation which takes place in mitochondria.
Introduction:
Neisseria gonorrhea is the gram negative bacteria that infect the female genital tractand it is a causative agent of gonorrhea.
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A patient develops a blood infection with a capsule-producing strain of E.
coli. Phagocytosis by macrophage will be essential to destroy the bacteria
and resolve the infection. Which of the following will be dirertly
required to allow ADCC-opsonization of the encapsulated E. coli:
O Toll-like receptor (TLR)-induced secretion of tumor necrosis factor alpha
O Release of C3a to the extracellular fluids
O Presence of MHC II on the surface of the macrophage
O Presence of IgG receptors (Fc-gamma-R) on the macrophage
All of the answers apply
Shigella, Mycobacterium, and numerous other pathogens have developed mechanisms that prevent them from being killed by phagocytes.
Suggest 2 or 3 factors that help them avoid destruction by the powerful antiseptics in macrophages
Suggest the potential implications that these infected macrophages can have on the development of disease
Toll-like receptors represent an ancient pathogen-recognition system. The first pattern recognition receptor (PRR) important in innate immune responses was discovered in the fruit fly Drosophila melanogaster. Stimulation of this receptor, called Toll, induces:
The synthesis of prostaglandins and leukotrienes
The inflammatory response in Drosophila hemolymph vessels
The production of antimicrobial peptides
The recruitment of phagocytic cells to the site of infection
The activation of Drosophila complement
Chapter 15 Solutions
Microbiology: An Introduction (13th Edition)
Ch. 15 - Compare pathogenicity with virulence.Ch. 15 - How are capsules and cell wall components related...Ch. 15 - Prob. 3RCh. 15 - Explain how drugs that bind each of the following...Ch. 15 - Prob. 5RCh. 15 - Prob. 6RCh. 15 - Prob. 7RCh. 15 - Which of the following genera is the most...Ch. 15 - How can viruses and protozoa avoid being killed by...Ch. 15 - Prob. 10R
Ch. 15 - The removal of plasmids reduces virulence in which...Ch. 15 - Prob. 2MCQCh. 15 - Prob. 3MCQCh. 15 - All of the following can occur during bacterial...Ch. 15 - The ID50 for Campylobacter sp. is 500 cells; the...Ch. 15 - Prob. 6MCQCh. 15 - A drug that binds to mannose on human cells would...Ch. 15 - The earliest smallpox vaccines were infected...Ch. 15 - Prob. 9MCQCh. 15 - Which of the following statements is true? a. The...Ch. 15 - Prob. 1ACh. 15 - Prob. 2ACh. 15 - Prob. 3ACh. 15 - How do each of the following strategies contribute...Ch. 15 - On July 8, a woman was given an antibiotic for...Ch. 15 - Explain whether each of the following examples is...Ch. 15 - Cancer patients undergoing chemotherapy are...
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- During inflammaion, host tissue may be damaged owing to the release of toxic oxygen derivatives produced by activated phagocytes. List some of hese toxic species and explain what cellular/biochemical mechanisms limit these damaging off-target effects.arrow_forwardA phagocyte enters tissues by: chemotaxis leukocytosis diapedesis marginationarrow_forwardIntercellular communication has been studied in detail in Myxococcus xanthus. Review the life cycle of this developmentally complex microbe and indicate at what points during this process intercellular signaling molecules might be exchanged and the message they would convey.arrow_forward
- Mycobacteria are intracellular pathogens that have adapted to life inside phagocytic cells, such as macrophages. These intracellular bacteria are taken up by phagocytosis, similar to other pathogens, but the bacteria are not killed. One possible mechanism that could account for this immune evasion by mycobacteria is their ability to: Prevent induction of nitric oxide production in the phagosome Prevent the acidification of phagosomes Prevent the expression of antimicrobial peptides in the phagosome Prevent fusion of phagosomes with lysosomes Kill the macrophage before it kills themarrow_forwardHow does Mycobacterium tuberculosis gain access through that preferred portal of entry Explain how the Mycobacterium tuberculosis is able to evade innate human host defenses that prevent this from occurring. discuss specific components of your pathogen. (Examples may include capsules, cell wall components, exoenzymes, antigenic variation and penetration of the host cell cytoskeleton.)arrow_forwardPatients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results, in the figure below, were obtained. Based on these data, the identity of the green neutrophil mediator in the figure below is likely to be: Complement factor B The C3 convertase Factor P (properdin) C3b Mannose-binding lectin (MBL)arrow_forward
- Encapsulated organisms can be phagocytized once antibodies against the capsule have been produced. Why would this be so?arrow_forwardTrue/False: Neutrophils regulate the production of active cathelicidins (a class of antimicrobial peptides) by segregating the inactive propeptide from the processing enzyme that cleaves and activates it in two different types of cytoplasmic granules. These two types of granules are induced to fuse with phagosomes after ingestion of microbes, bringing the processing enzyme and the propeptide together.arrow_forwardMycobacterium tuberculosis recruits phagocytes to the site of infection. Based on this information, which of the three methods shown here does the bacterium likely use to avoid being destroyed?arrow_forward
- All of the following are methods intracellular pathogens can use to survive inside a host cell EXCEPT create a capsule. Escape the phagosome. survive in the phagolysosome. prevent phagosome-lysosome fusion.arrow_forwardTLR-4 recognizes bacterial lipopolysaccharide in association with the host accessory proteins MD-2 and CD14. True/False: All mammalian TLRs have been shown to directly bind to microbial products, leading to TLR signaling.arrow_forwardThe process of macrophages bringing microbes inside the cell to destroy them is called: diapedesis chemotaxis leukocytosis phagocytosisarrow_forward
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