Action of insulin binding and EGF binding on the chimeric receptor should be determined. Concept introduction: The cell-surface receptors for EGF and insulin are thought to have the same origin because of the similarity in cysteine-rich residues in their EC domains. Moreover, they both have tyrosine kinase domains. The only difference is found in their catalytic site, which is specific for ligands and biological functions.

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Chapter 14, Problem 15P

Interpretation Introduction

Interpretation:

Action of insulin binding and EGF binding on the chimeric receptor should be determined.

Concept introduction:

The cell-surface receptors for EGF and insulin are thought to have the same origin because of the similarity in cysteine-rich residues in their EC domains. Moreover, they both have tyrosine kinase domains. The only difference is found in their catalytic site, which is specific for ligands and biological functions.

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