Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 14, Problem 11P
Interpretation Introduction
Interpretation:
The mechanism of phosphorylation events in insulin kinases should be determined.
Concept introduction:
Insulin is a peptide hormone, which is secreted by the beta cells of the pancreas. The function of insulin is to promote the conversion of glucose into glycogen and decrease its output into the blood. In the muscle cells, insulin stimulates GLUT4 to transport glucose inside the cell. The receptor for the insulin belongs to the receptor-tyrosine kinase family.
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True or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor involves certain types of chemical bonds. Explain your answer in detail.. ( please do not copy off of another source.. e.g chegg)
True or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor alone determines the sensitivity of a cell to the agonist peptide.
Assighment.
Create a diagram which illustrates the typical signalling mechanism of action of
each of the four common classes of receptor (e.g. kinase-linked receptors etc.)
and possible routes of communication (autocrine etc.). Your diagram should
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indicate the different pathways that are activated. It should include a specific
example of a receptor, ligand and signalling pathway for each general class.
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DO NOT use any of the ligand-receptor combinations provide to you in the
Learning Materials to date - research and create a diagram for a novel pathway
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