Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 14, Problem 23P
Interpretation Introduction
Interpretation:
The number of cell surface receptor is to be calculated.
Concept introduction:
Cell membrane is bi-layer of phospholipids with many proteins and cholesterols. Proteins in the surface may be of two types. One is peripheral other is integral membrane protein. often integral proteins play role of receptor for various ligand molecules known as primary receptors.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand.
What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?
Frog poison. Batrachotoxin (BTX) is a steroidal alkaloid from the skin
of Phyllobates terribilis, a poisonous Colombian frog (the source of
the poison used on blowgun darts). In the presence of BTX, Na+Na*
channels in an excised patch stay persistently open when the
membrane is depolarized. They close when the membrane is
repolarized. Which transition is blocked by BTX?
SIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met).
Protease with mannose-6-phosphate
Where is the receptor for this protein located?
Where is the final destination of this polypeptide?
What happens to the receptor after protein transport?
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Assighment. Create a diagram which illustrates the typical signalling mechanism of action of each of the four common classes of receptor (e.g. kinase-linked receptors etc.) and possible routes of communication (autocrine etc.). Your diagram should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. For each of the examples describe the mechanism of action in the form below. DO NOT use any of the ligand-receptor combinations provide to you in the Learning Materials to date - research and create a diagram for a novel pathway instead!arrow_forwardPlease help me with this question. More than one answer may be correct. THe graph relating to the information is included below. The above figures show the rate of actin polymerization in the presence of various concentration of profilin (Pfn). In the top figure, flourescence intensity is a measure of total actin that has been polymerized, and this is plotted versus time in seconds. The shade of blue of the lines in the top figure correspond to the shaded blue bars representing various concentrations of profilin in the lower figure. The lower graph shows the initial rates of polymerization of actin plotted again concentration. Which of the following is true: Question 21 options: profilin in a molecular motor profilin is a promoter of actin polymerization profilin replaced G-actin in an F-actin strand and breaks the filament profilin is an inhibitor of actin polymerization profilin binds to G-actin, preventing it from polymerizingarrow_forwardSIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met). Catalase with H2N-...KERINGKERIANGEKSAMSKL-COOH What is the name of the specific receptor of this polypeptide? The receptor may also have what alternative function?arrow_forward
- Plesae ASAP. thanku Which of the following is not true about the glutamate family of ligand-gated ion channels? a. members are AMPA, kinase, and NMDA channels b. they are cation permable c. channels subunits have 3 full transmembrane doamins d. they require 5 subunits to amke a functional channelarrow_forwardInducers and Inhibitors of AEP. Short peptides such as legumain stabilization and activity modulation (LSAM) domain and αvβ3 integrin could enhance the activity of AEP. LSAM domain known as the prodomain of AEP blocks substrate binding before activation. This prodomain has a helical structure and two independent peptides. One is an activation peptide (AP, K287 to N323), and the other is a LSAM domain. LSAM domain remains even after AP is cleaved and released from protease at neutral pH via electrostatic interaction. AEP without LSAM domain has a lower melting temperature than AEP with LSAM domain [77, 117]. Another short peptide, αvβ3 integrin, can directly interact with AEP, and after forming a complex, the optimal pH for AEP activity is increased from 5.5 to 6.0. It indicates that αvβ3 binding could induce conformational stabilization of AEP accompanied by deprotonated C189. αvβ3 does not directly interact with the AEP active site; however, AEP docks to the αvβ3 RGD-binding site…arrow_forward1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.arrow_forward
- Only a few. Why do only a small number of sodium ions need to flow through the Na+Na* channel to change the membrane potential significantly?arrow_forwardPlease help me with this question. More than one answer may be correct. THe graph relating to the information is included below. The figure shows the number of cells that have clusters of IRE1 molecules after those cells are treated with various levels of thapsigargin (Tg), a chemical that can induce ER stress. IRE1 can form these clusters when ER stress is induced and this clustering can cause activation of RNAse activity in IRE1. In this experiment, normal IRE1 was used (IRE1α) that can bind to Sec61, along with a modified version of IRE1 that binds to Sec61 more weakly than normal IRE1 (wIRE1α), and another modified version that binds to Sec61 more strongly than normal IRE1 (sIRE1α). From this figure you can conclude that: Question 18 options: IRE1 binding to Sec61 promotes the formation of IRE1 clumps IRE1 binding to Sec61 prevents the formation of IRE1 clumps co-translational translocation is a key process the golgi aparatus is heavily involved in the unfolded protein response The…arrow_forwardNeed help. A protein X binds Ligand Y. The kon characterizing this binding is 1 x 106 M-1s-1, koff is 2 x 10-3 M-1s-1. In your in vitro X-Y binding experiment, at what concentration of Ligand Y half of the Protein X would be bound to Y. Assume that the binding is according to the Lock-and-key modelarrow_forward
- Please help me with this question. PLEase give me the right answer and for number 2 WRITE AT LEAST A PARAGRAPGH and dont copy from internet.arrow_forwardCell communication .a) There are six main principles for transmitting a chemical signal between cells, mention and describe two. b) How does a signal binding to the cell's surface reach all the way into the nucleus? c. What does it mean that a signal is G protein connected?arrow_forwardDraw a cell. Draw a receptor that binds to a signaling molecule on the outside of the cell and a receptor that binds to a signaling molecule on the inside of the cell. What property does a signaling molecule that crosses the cell membrane (plasma membrane) need?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning