Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 12, Problem 10PDQ
Describe the transitions that occur as nucleosomes are coiled and folded, ultimately forming a chromatid.
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DEfine Nucleosome
Human cells normally have 46 chromosomes. For each of the following
stages, state the number of chromosomes and the number of DNA molecules
found in these chromosomes that are present in a human cell.
a) Metaphase of mitosis
Metaphase I of meiosis
c) Telophase of mitosis (after cytokinesis)
The interphase is the part of the eukaryotic cell cycle that is most transcriptionally active. Gene regulation during this phase involves changes in the chromatin.
a) What is chromatin?
b) How can the chromatin structure change?
Chapter 12 Solutions
Concepts of Genetics (12th Edition)
Ch. 12 - In bacteriophages and bacteria, the DNA is almost...Ch. 12 - After salivary gland cells from Drosophila are...Ch. 12 - If a human nucleus is 10 m in diameter, and it...Ch. 12 - Roberts syndrome is a rare inherited disorder...Ch. 12 - Prob. 2CSCh. 12 - Roberts syndrome is a rare inherited disorder...Ch. 12 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 12 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 12 - Contrast the size of the single chromosome in...Ch. 12 - Describe the structure of giant polytene...
Ch. 12 - What genetic process is occurring in a puff of a...Ch. 12 - During what genetic process are lampbrush...Ch. 12 - Why might we predict that the organization of...Ch. 12 - Describe the sequence of research findings that...Ch. 12 - Describe the molecular composition and arrangement...Ch. 12 - Describe the transitions that occur as nucleosomes...Ch. 12 - Provide a comprehensive definition of...Ch. 12 - Mammals contain a diploid genome consisting of at...Ch. 12 - Assume that a viral DNA molecule is a 50-m-long...Ch. 12 - How many base pairs are in a molecule of phage T2...Ch. 12 - Examples of histone modifications are acetylation...Ch. 12 - Contrast the structure of SINE and LINE DNA...Ch. 12 - Variable number tandem repeats (VNTRs) are...Ch. 12 - It has been shown that infectious agents such as...Ch. 12 - Cancer can be defined as an abnormal proliferation...Ch. 12 - In a study of Drosophila, two normally active...Ch. 12 - Prob. 21ESPCh. 12 - An article entitled Nucleosome Positioning at the...Ch. 12 - Prob. 23ESPCh. 12 - Following is a diagram of the general structure of...Ch. 12 - Microsatellites are currently exploited as markers...Ch. 12 - At the end of the short arm of human chromosome 16...
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- Draw a single duplicated chromosome, labeling the chromatid(s) and centromerearrow_forwardDescribe the relationship between linkage groups andchromosomes.arrow_forwardA cell in G1 of interphase has 8 chromatins. How many chromosomes and how many DNA molecules will be found per cell as this cell progresses through the following stages: a) metaphase b) anaphase c) after cytokinesis in mitosis d) metaphase I e) anaphase I f) metaphase II g) anaphase II h) after cytokinesis of meiosis IIarrow_forward
- Discuss the levels of chromosomal organization with reference to the following terms: a. nucleotide b. DNA double helix c. histones d. nucleosomes e. chromatinarrow_forwardIn eukaryotic chromosomes, DNA wraps around _________. a. histone proteins c. centromeres b. sister chromatids d. nucleosomesarrow_forwardIf a typical somatic cell has 12 chromosomes, how many chromatids and DNA molecules are expected in each cell of that organism?arrow_forward
- Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forwardDifferentiate between these terms: chromosome, chromatin,and chromatid.arrow_forwardWhat structure is formed by when two sister chromatids areheld together by a centromere?arrow_forward
- Which of the following events happen during interphase? CHOOSE ALL THAT ARE CORRECT. A) DNA replication b) centriole duplication c)increase in cell size d) separate of sister chromatids e) assembly of the mitotic spindle f) formation of the nuclear envelopearrow_forwardA bivalent consists of: A Two chromatids and one centromere B Four chromatids and two centromeres C Two chromatids and two centromeres D Four chromatids and four centromeresarrow_forwardThe same chromosome can look very different depending on when in meiosis it is observed. Explain fully why this is so and also why the chromosome is less condensed during some parts of the cell cycle? How many DNA molecules does each chromosome contain at the beginning of Prophase I? Use the following terms in your explanation: chromatin, histone, chromatid, centromere.arrow_forward
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