Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 5P
Human late prophase karyotypes have about
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The fruit fly Drosophila melanogaster has about 2 x 10^8 base pairs of DNA per haploid genome, of which about 75% in nonrepeated DNA. The DNA
is distributed among four pairs of homologous chromosomes, which have a total of about 5,000 visible bands when in polytene forms in the salivary
gland. The number of genes initially estimated from mutational studies was also about 5,000 but recent DNA sequencing studies suggest that the
gene number may be somewhat higher.
a. Why was it tempting to speculate that each band corresponds to a single gene? What does this suggest about the number of different proteins
Drosophila can make? Does that seem like a reasonable number to you?
b. Assuming all the nonrepeated DNA is uniformly distributed in the chromosomes, how much nonrepeated DNA (in base pairs) is there in average
band?
An STR on chromosome 5 is very closely linked to a gene involved in a dominant metabolism disorder (one one copy of the mutation causes the disease). There are four different alleles of the STR (Q, B, S, and L), each with different numbers of GATCTCG repeats. The S allele
has 2 repeats, the B allele has 7 repeats, the Q allele has 10 repeats, and the L allele has 5 repeats.
Part 1
Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel.
Move the letter of each allele to its correct position at the left of Lane 1 to indicate where each allele runs on the gel.
0000
Gabriel
Andre
Lane 1
O Maria
Andre Maria Juliana
B L
Part 2
Andre and Maria are the parents in this family; all others shown on the gel are children. Daughter Juliana is born with the metabolism disorder, but daughter Camila does not have the disorder. Assuming no recombination between the STR…
Chapter 10 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 10 - 10.1 Give descriptions for the following...Ch. 10 - 10.2 The human genome contains contains base...Ch. 10 - In eukaryotic DNA, Where are you most likely to...Ch. 10 - 10.4 Describe the importance of light and dark G...Ch. 10 - Human late prophase karyotypes have about 2000...Ch. 10 - Prob. 6PCh. 10 - From the following list, identify the types...Ch. 10 - 10.8 If the haploid number for a plant species is...Ch. 10 - Mating between a male donkey (2n=64) and a female...Ch. 10 - A researcher interested in studying a human gene...
Ch. 10 - 10.11 In what way does position effect variegation...Ch. 10 - 10.12 A pair of homologous chromosomes in...Ch. 10 - 10.13 An animal heterozygous for a reciprocal...Ch. 10 - Dr. Ara B. Dopsis has an idea he thinks will be a...Ch. 10 - A normal chromosome and its homolog carrying a...Ch. 10 - The accompanying chromosome diagram represents a...Ch. 10 - 10.17 Histone protein isolated from pea plants...Ch. 10 - 10.18 A survey of organisms living deep in the...Ch. 10 - In humans that XX/XO mosaics, the phenotype is...Ch. 10 - 10.20 A plant breeder would like to develop the...Ch. 10 - In Drosophilia, seven partial deletion (1to7)...Ch. 10 - Two experimental varieties of strawberry are...Ch. 10 - 10.23 In the tomato, Solanum esculentum, tall ()...Ch. 10 - A boy with Down syndrome (trisomy 21) has 46...Ch. 10 - Experimental evidence demonstrates that the...Ch. 10 - Prob. 26PCh. 10 - Genomic DNA from the nematode worm...Ch. 10 - 10.28 A small population of deer living on an...Ch. 10 - A eukaryote with a diploid number of 2n=6 carries...Ch. 10 - Prob. 30PCh. 10 - For the following crosses, determine as accurately...Ch. 10 - A healthy couple with a history of three previous...
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- In a species of rat, the map unit distance between genes A, B, C and D were asfollows: (in the picture) (a) What is the order of these genes on the chromosome? (b) What is the map unit distance between B and D?arrow_forwardARVC5 is a disorder characterized by the replacement of healthy heart tissue with fatty fibrous tissue. Recent research has discovered the mutated gene that causes the disorder is on chromosome 3. People who have the mutation have a GCG triplet instead of the normal ACA triplet. The following is a section of a gene on chromosome 3: GGT GCG ACA ATT 1. Complete the following table. AA DNA sense strand DNA antisense strand GGT GCG ACA ATT mRNA tRNA 2. Indicate the change in the amino acid sequence resulting from the mutation in the gene described above., B I 123 ||| 14 E GO LG US X₂ x²arrow_forwardIn tomato plants, the genes for fruit colour (C), fruit fructose content (F), fruit length (L), and plant height (H) are all found on chromosome 4. Map distances between the four genes are shown below. Genes Distance in Map Units H and F 40 F and L 12 C and F 75 L and C 87 L and H 52 Sketch and label a gene map to identify the order of the four genes on chromosome 1 in tomato plants.arrow_forward
- Referring to Figure 17-19, draw a diagram showing theprocess whereby an inversion formed from crossing overcould generate a normal sequence.arrow_forwardIn Drosophila, the genes for eye color, wing shape, and wing length are located on chromosome II. Purple eyes (pr), arc bent wings (a), and vestigial wings (vg) are the mutant forms of the wild type traits red eyes, straight wings, and long wings, respectively. You've discovered some data in your genetics laboratory which indicates that the distance between vg and pr is 12.5 m.u., the distance between a and pr is 44.7 m.u., and the distance between a and vg is 32.2 m.u. From this information, deduce the order of these genes on chromosome II and identify which gene is in the middle. A. a B. pr C. not enough information to tell D. vgarrow_forwardThe dominant condition elliptocytosis causes red blood cells to become misshapen into oval-shaped cells. One of the genes responsible for the abnormal shape encodes the band 4.1 protein that together with ankyrin and other scaffold proteins creates and maintains the spherical concave shape of a normal red blood cell. The gene for band 4.1 protein, EPB41, is found on the p arm of chromosome 1. This is very close to the gene encoding the red blood cell Rhesus (Rh) blood type, either phenotype + (dominant) or - (recessive), with a recombination frequency of 2%. This means that 98% of the time alleles for these two genes are linked and are transmitted together. Diane and Jack are siblings, and both have elliptocytosis and Rh+ blood type. Due to the elliptocytosis, both had emergency splenectomies after having severe anemia. Their younger brother, Devonté, has not yet shown signs of elliptocytosis, but has Rh- blood. André, their dad, also has elliptocytosis and Rh+ blood; while their…arrow_forward
- Assuming that 32 million histone octamers arerequired to package the human genome, how many his-tone molecules must be transported per second pernuclear pore complex in cells whose nuclei contain 3000nuclear pores and are dividing once per day?arrow_forwardFriedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease that causes a lack of voluntary coordination of muscle movements. Affected individuals are homozygous for an unusually large number (expansion) of repeats of a trinucleotide sequence (GAA) in the first intron of the X25 gene. Unaffected individuals typically have between 7 and 38 repeats of the trinucleotide (GAAGAAGAAGAA…). FRDA patients have anywhere from 66 to over 1,700 repeats. To understand how the GAA trinucleotide expansion leads to FRDA, researchers looked at X25 gene expression by extracting RNA from affected and unaffected patients and doing a northern blot analysis (see the figure below): In panel “a,” the researchers used a probe to detect X25 mRNA. In panel “b,” the researchers used a probe on a duplicate of the original blot to detect human GAPDH mRNA (GAPDH is an enzyme involved in glycolysis). The sample labeled “YR” is mRNA from yeast cells that was used as a control. Explain…arrow_forwardAt the end of the short arm of human chromosome 16 (16p), several genes associated with disease are present, including thalassemia and polycystic kidney disease. When that region of chromosome 16 was sequenced, gene-coding regions were found to be very close to the telomere-associated sequences. Could there be a possible link between the location of these genes and the presence of the telomere-associated sequences? What further information concerning the disease genes would be useful in your analysis?arrow_forward
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