Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 10P

A researcher interested in studying a human gene on chromosome 21 and another gene on the X chromosome 21 and another gene on the X chromosome uses FISH probes to locate each gene. The chromosome 21 probe produces green fluorescent color, and the X chromosome probe produces red fluorescent color.

If the subject studied is female, how many green and red spots will be detected? Explain your answer.

If the subject studied is male, how many green and red spots will be detected? Explain your answer.

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In the past, the IOC has employed two genetic sex- determination tests. The Barr body test screens for the presence of two X chromosomes. In XX somatic cells, one copy of the X chromosome condenses into a largely inactive structure called a Barr body, which can be seen using a light microscope. In more recent years, a polymerase chain reaction-based screen has been used to amplify the DNA sequence of the SRY gene, which is found only on the Y chromosome. Based on their karyotypes, what would be the outcome of these two tests for each of the four individuals? Drag the labels to indicate the presence or absence of a Barr body and the SRY gene sequence.
Give examples of convetional stains used for karyotyping and describe each briefly. Include which part(s) of the chromosomes these stains visualize. What is an ideogram? What is its significance? What are some of the medical applications of karyotyping?
The chromosomes drawn below are found in a human skin cell. The lines represent the chromosomes themselves. The letters indicate the location of a particular version of a gene. d) T/F If the protein produced by the BA gene is involved in the formation of ovaries, then the BA gene is likely located on a sex chromosome. e) T/F Because the genes shown here are found in skin cells, these genes code for proteins required for skin cell function.

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Genetic Analysis: An Integrated Approach (3rd Edition)

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Genome Annotation, Sequence Conventions and Reading Frames; Author: Loren Launen;https://www.youtube.com/watch?v=MWvYgGyqVys;License: Standard Youtube License