Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 32P

A healthy couple with a history of three previous spontaneous abortions has just had a child with  cri-du-chat the syndrome, a disorder caused by a terminal deletion of the chromosome 5 . Their physician orders karyotype analysis of both parents and of the child. The karyotype results for chromosomes   5 and   12 are shown here.

Chapter 10, Problem 32P, A healthy couple with a history of three previous spontaneous abortions has just had a child with

Are the chromosomes in the child consistent with those expected in a case of cri-du-chat syndrome? Explain your reasoning.

Which parent has an abnormal karyotype? How can you tell? What is the nature of the abnormality?

Why does this parent have a normal phenotype?

Diagram the pairing of the abnormal chromosomes.

What segregation pattern occurred to produce the gamete involved in fertilization of the child with cri-du-chat syndrome?

What is the approximate probability that the next child of this couple will have cri-du-chat a syndrome?

Do the karyotypes of the parents help explain the occurrence of the three previous spontaneous abortions? Explain.

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The Klinefelter syndrome (disomy of the X chromosome in males) is a genetic disease caused by aneuploidy of the sex chromosomes in humans. Patients with the 47,XXY karyotype are male. Describe two genetic scenarios leading to patients with the Klinefelter syndrome.
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?
A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. a. List all the different types of gametes that might be produced by the man. b. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman? c. If trisomies and monosomies entailing chromosomes 13 and 22 are lethal, approximately what proportion of the surviving offspring are expected to be carriers of the translocation?

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Genetic Analysis: An Integrated Approach (3rd Edition)

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