Which of the following statements regarding the fidelity of DNA replication is true? OI. DNA polymerase has a 3'-5' exonuclease activity that removes incorrectly paired nucleotides. O The DNA polymerase active site is highly flexible and can easily "fit" incorrectly paired incorporated nucleotides. DNA polymerase never makes an error in the nucleotide being incorporated. O II. -v The stability of base pairing is not a factor in controlling the fidelity of nucleotide incorporation during replication. y DNA polymerase has evolved to make errors at a relatively high rate because this is what drives evolution.

Human Anatomy & Physiology (11th Edition)
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Which of the following statements regarding the fidelity of DNA replication is true?
DNA polymerase has a 3'-5' exonuclease activity that removes incorrectly paired nucleotides.
The DNA polymerase active site is highly flexible and can easily 'fit' incorrectly paired incorporated nucleotides.
I.
DNA polymerase never makes an error in the nucleotide being incorporated.
The stability of base pairing is not a factor in controlling the fidelity of nucleotide incorporation during replication.
IV.
DNA polymerase has evolved to make errors at a relatively high rate because this is what drives evolution.
OV.
Transcribed Image Text:Which of the following statements regarding the fidelity of DNA replication is true? DNA polymerase has a 3'-5' exonuclease activity that removes incorrectly paired nucleotides. The DNA polymerase active site is highly flexible and can easily 'fit' incorrectly paired incorporated nucleotides. I. DNA polymerase never makes an error in the nucleotide being incorporated. The stability of base pairing is not a factor in controlling the fidelity of nucleotide incorporation during replication. IV. DNA polymerase has evolved to make errors at a relatively high rate because this is what drives evolution. OV.
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