Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Use this mRNA coding sequence as your starting point. This sequence begins with a start codon and ends with a stop codon, so it is only looking at the region of DNA that directly encodes a protein sequence.

5’-AUGCACAAAUUAGAGUACCCCCCAGGAAGGUAG-3’

Make the following mutation in this sequence by changing/adding/removing only one nucleotide. Make the mutation easy to see (a different color, circled, something like that)

A nonsense mutation

TABLE 13.1
The Genetic Code
First base
U
UUU Phenylalanine
UUC (Phe)
UUA
UUG
CUU
CUC
CUA
CUG
A AUA
AUG
AUU
AUC Isoleucine (lle)
GUU
GUC
Leucine (Leu)
GUA
GUG
Leucine (Leu)
Methionine (Met);
start codon
Valine (Val)
UCU
UCC
UCA
UCG
CU CU
UU UU
UC AG
CCA
CCG
ACU
ACC
A CA
ACG
GGGG
UU UU
UUAG
Second base
Serine (Ser)
Proline (Pro)
Threonine (Thr)
Alanine (Ala)
(_))
UAU
UAC
UAA Stop codon
UAG Stop codon
CAU
CAC
A
Tyrosine (Tyr)
Histidine (His)
CAA Glutamine (Gln)
CAG
AAA
AAG
A A U Asparagine
AAC (Asn)
Lysine (Lys)
GAU Aspartic acid
GAC (Asp)
GAA Glutamic acid
GAG (Glu)
UGU Cysteine (Cys)
UGC
UGA Stop codon
UGG Tryptophan (Trp)
UU UU
SSSS
AGU
AG C
AGA
AGG
SU G
Arginine (Arg)
Serine
Arginine (Arg)
(Ser)
Glycine (Gly)
DUAG
C
UCAG
DUAG DUAG
Third base
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Transcribed Image Text:TABLE 13.1 The Genetic Code First base U UUU Phenylalanine UUC (Phe) UUA UUG CUU CUC CUA CUG A AUA AUG AUU AUC Isoleucine (lle) GUU GUC Leucine (Leu) GUA GUG Leucine (Leu) Methionine (Met); start codon Valine (Val) UCU UCC UCA UCG CU CU UU UU UC AG CCA CCG ACU ACC A CA ACG GGGG UU UU UUAG Second base Serine (Ser) Proline (Pro) Threonine (Thr) Alanine (Ala) (_)) UAU UAC UAA Stop codon UAG Stop codon CAU CAC A Tyrosine (Tyr) Histidine (His) CAA Glutamine (Gln) CAG AAA AAG A A U Asparagine AAC (Asn) Lysine (Lys) GAU Aspartic acid GAC (Asp) GAA Glutamic acid GAG (Glu) UGU Cysteine (Cys) UGC UGA Stop codon UGG Tryptophan (Trp) UU UU SSSS AGU AG C AGA AGG SU G Arginine (Arg) Serine Arginine (Arg) (Ser) Glycine (Gly) DUAG C UCAG DUAG DUAG Third base
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